Flavonoid Glycosides from Endemic Bulgarian <i>Astragalus aitosensis</i> (Ivanisch.)
<i>Astragalus</i> is a very interesting plant genus, well-known for its content of flavonoids, triterpenes and polysaccharides. Its secondary metabolites are described as biologically active compounds showing several activities, e.g., immunomodulating, antibacterial, antiviral and hepato...
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doaj-d0ba67fed3e844db96a2803da9e3ba502020-11-24T23:31:34ZengMDPI AGMolecules1420-30492019-04-01247141910.3390/molecules24071419molecules24071419Flavonoid Glycosides from Endemic Bulgarian <i>Astragalus aitosensis</i> (Ivanisch.)Hristo Vasilev0Samir Ross1Karel Šmejkal2Petr Maršík3Dagmar Jankovská4Jaroslav Havlík5Ondřej Veselý6Department of Pharmacognosy, Faculty of Pharmacy, Medical University–Sofia, 2 Dunav str., 1000 Sofia, BulgariaNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USADepartment of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, 61242 Brno, Czech RepublicDepartment of Food Science, Czech University of Life Sciences Prague, Kamycka 129, 165 00 Prague 6–Suchdol, Czech RepublicDepartment of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, 61242 Brno, Czech RepublicDepartment of Food Science, Czech University of Life Sciences Prague, Kamycka 129, 165 00 Prague 6–Suchdol, Czech RepublicDepartment of Food Science, Czech University of Life Sciences Prague, Kamycka 129, 165 00 Prague 6–Suchdol, Czech Republic<i>Astragalus</i> is a very interesting plant genus, well-known for its content of flavonoids, triterpenes and polysaccharides. Its secondary metabolites are described as biologically active compounds showing several activities, e.g., immunomodulating, antibacterial, antiviral and hepatoprotective. This inspired us to analyze the Bulgarian endemic <i>A. aitosensis</i> (Ivanisch.) to obtain deeper information about its phenolic components. We used extensive chromatographic separation of <i>A. aitosensis</i> extract to obtain seven phenolic compounds (<b>1</b>–<b>7</b>), which were identified using combined LC-MS and NMR spectral studies. The 1D and 2D NMR analyses and HR-MS allowed us to resolve the structures of known compounds <b>5</b>–<b>7</b> as isorhamnetin-3-<i>O</i>-robinobioside, isorhamnetin-3-<i>O</i>-(2,6-di-<i>O</i>-α-rhamno-pyranosyl-β-galactopyranoside), and alangiflavoside, respectively, and further comparison of these spectral data with available literature helped us with structural analysis of newly described flavonoid glycosides <b>1</b>–<b>4</b>. These were described in plant source for the first time.https://www.mdpi.com/1420-3049/24/7/1419<i>Astragalus aitosensis</i>flavonoidglycoside |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hristo Vasilev Samir Ross Karel Šmejkal Petr Maršík Dagmar Jankovská Jaroslav Havlík Ondřej Veselý |
spellingShingle |
Hristo Vasilev Samir Ross Karel Šmejkal Petr Maršík Dagmar Jankovská Jaroslav Havlík Ondřej Veselý Flavonoid Glycosides from Endemic Bulgarian <i>Astragalus aitosensis</i> (Ivanisch.) Molecules <i>Astragalus aitosensis</i> flavonoid glycoside |
author_facet |
Hristo Vasilev Samir Ross Karel Šmejkal Petr Maršík Dagmar Jankovská Jaroslav Havlík Ondřej Veselý |
author_sort |
Hristo Vasilev |
title |
Flavonoid Glycosides from Endemic Bulgarian <i>Astragalus aitosensis</i> (Ivanisch.) |
title_short |
Flavonoid Glycosides from Endemic Bulgarian <i>Astragalus aitosensis</i> (Ivanisch.) |
title_full |
Flavonoid Glycosides from Endemic Bulgarian <i>Astragalus aitosensis</i> (Ivanisch.) |
title_fullStr |
Flavonoid Glycosides from Endemic Bulgarian <i>Astragalus aitosensis</i> (Ivanisch.) |
title_full_unstemmed |
Flavonoid Glycosides from Endemic Bulgarian <i>Astragalus aitosensis</i> (Ivanisch.) |
title_sort |
flavonoid glycosides from endemic bulgarian <i>astragalus aitosensis</i> (ivanisch.) |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2019-04-01 |
description |
<i>Astragalus</i> is a very interesting plant genus, well-known for its content of flavonoids, triterpenes and polysaccharides. Its secondary metabolites are described as biologically active compounds showing several activities, e.g., immunomodulating, antibacterial, antiviral and hepatoprotective. This inspired us to analyze the Bulgarian endemic <i>A. aitosensis</i> (Ivanisch.) to obtain deeper information about its phenolic components. We used extensive chromatographic separation of <i>A. aitosensis</i> extract to obtain seven phenolic compounds (<b>1</b>–<b>7</b>), which were identified using combined LC-MS and NMR spectral studies. The 1D and 2D NMR analyses and HR-MS allowed us to resolve the structures of known compounds <b>5</b>–<b>7</b> as isorhamnetin-3-<i>O</i>-robinobioside, isorhamnetin-3-<i>O</i>-(2,6-di-<i>O</i>-α-rhamno-pyranosyl-β-galactopyranoside), and alangiflavoside, respectively, and further comparison of these spectral data with available literature helped us with structural analysis of newly described flavonoid glycosides <b>1</b>–<b>4</b>. These were described in plant source for the first time. |
topic |
<i>Astragalus aitosensis</i> flavonoid glycoside |
url |
https://www.mdpi.com/1420-3049/24/7/1419 |
work_keys_str_mv |
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