A novel microRNA-132-sirtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis [corrected].

A novel microRNA-132-sirtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis [corrected].

Clinical trial results demonstrating that B-cell depletion substantially reduces new relapses in patients with multiple sclerosis (MS) have established that B cells play a role in the pathophysiology of MS relapses. The same treatment appears not to impact antibodies directed against the central ner...

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Main Authors: Yusei Miyazaki, Rui Li, Ayman Rezk, Hétoum Misirliyan, Craig Moore, Nasr Farooqi, Mayra Solis, Lorna Galleguillos Goiry, Omar de Faria Junior, Van Duc Dang, David Colman, Ajit Singh Dhaunchak, Jack Antel, Jennifer Gommerman, Alexandre Prat, Simon Fillatreau, Amit Bar-Or, CIHR/MSSC New Emerging Team Grant in Clinical Autoimmunity, MSSRF Canadian B cells in MS Team
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4138149?pdf=render

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