Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk
<p>Abstract</p> <p>Background</p> <p>Tau abnormal hyperphosphorylation and the formation of neurofibrillary tangles in AD brain is the result of upregulation of tau kinases and downregulation of tau phosphatases.</p> <p>Methods</p> <p>In a group...
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doaj-d0c5ed539cee41988dd42e2b43cc0c3f2020-11-25T01:46:19ZengBMCBMC Research Notes1756-05002011-09-014132710.1186/1756-0500-4-327Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease riskBerciano JoséValdivieso FernandoFrank-García AnaDobato José LCalero MiguelPozueta AnaRodríguez-Rodríguez EloySánchez-Juan PascualMateo IgnacioVázquez-Higuera José LBullido Maria JCombarros Onofre<p>Abstract</p> <p>Background</p> <p>Tau abnormal hyperphosphorylation and the formation of neurofibrillary tangles in AD brain is the result of upregulation of tau kinases and downregulation of tau phosphatases.</p> <p>Methods</p> <p>In a group of 729 Spanish late-onset Alzheimer's disease (AD) patients and 670 healthy controls, we examined variations into a set of candidate genes (PPP2CA, PPP2R2A, ANP32A, LCMT1, PPME1 and PIN1) in the tau protein phosphatase-2A (PP2A) pathway, to address hypotheses of genetic variation that might influence AD risk.</p> <p>Results</p> <p>There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by age, gender or APOE ε4 allele.</p> <p>Conclusion</p> <p>Our negative findings in the Spanish population argue against the hypothesis that genetic variation in the tau protein phosphatase-2A (PP2A) pathway is causally related to AD risk</p> http://www.biomedcentral.com/1756-0500/4/327 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Berciano José Valdivieso Fernando Frank-García Ana Dobato José L Calero Miguel Pozueta Ana Rodríguez-Rodríguez Eloy Sánchez-Juan Pascual Mateo Ignacio Vázquez-Higuera José L Bullido Maria J Combarros Onofre |
spellingShingle |
Berciano José Valdivieso Fernando Frank-García Ana Dobato José L Calero Miguel Pozueta Ana Rodríguez-Rodríguez Eloy Sánchez-Juan Pascual Mateo Ignacio Vázquez-Higuera José L Bullido Maria J Combarros Onofre Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk BMC Research Notes |
author_facet |
Berciano José Valdivieso Fernando Frank-García Ana Dobato José L Calero Miguel Pozueta Ana Rodríguez-Rodríguez Eloy Sánchez-Juan Pascual Mateo Ignacio Vázquez-Higuera José L Bullido Maria J Combarros Onofre |
author_sort |
Berciano José |
title |
Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk |
title_short |
Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk |
title_full |
Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk |
title_fullStr |
Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk |
title_full_unstemmed |
Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk |
title_sort |
genetic variation in the tau protein phosphatase-2a pathway is not associated with alzheimer's disease risk |
publisher |
BMC |
series |
BMC Research Notes |
issn |
1756-0500 |
publishDate |
2011-09-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Tau abnormal hyperphosphorylation and the formation of neurofibrillary tangles in AD brain is the result of upregulation of tau kinases and downregulation of tau phosphatases.</p> <p>Methods</p> <p>In a group of 729 Spanish late-onset Alzheimer's disease (AD) patients and 670 healthy controls, we examined variations into a set of candidate genes (PPP2CA, PPP2R2A, ANP32A, LCMT1, PPME1 and PIN1) in the tau protein phosphatase-2A (PP2A) pathway, to address hypotheses of genetic variation that might influence AD risk.</p> <p>Results</p> <p>There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by age, gender or APOE ε4 allele.</p> <p>Conclusion</p> <p>Our negative findings in the Spanish population argue against the hypothesis that genetic variation in the tau protein phosphatase-2A (PP2A) pathway is causally related to AD risk</p> |
url |
http://www.biomedcentral.com/1756-0500/4/327 |
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