Dose-dependent T-cell Dynamics and Cytokine Cascade Following rVSV-ZEBOV Immunization

Dose-dependent T-cell Dynamics and Cytokine Cascade Following rVSV-ZEBOV Immunization

Background: The recent West African Ebola epidemic led to accelerated efforts to test Ebola vaccine candidates. As part of the World Health Organisation-led VSV Ebola Consortium (VEBCON), we performed a phase I clinical trial investigating rVSV-ZEBOV (a recombinant vesicular stomatitis virus-vectore...

Full description

Bibliographic Details
Main Authors:	Christine Dahlke, Rahel Kasonta, Sebastian Lunemann, Verena Krähling, Madeleine E. Zinser, Nadine Biedenkopf, Sarah K. Fehling, My L. Ly, Anne Rechtien, Hans C. Stubbe, Flaminia Olearo, Saskia Borregaard, Alen Jambrecina, Felix Stahl, Thomas Strecker, Markus Eickmann, Marc Lütgehetmann, Michael Spohn, Stefan Schmiedel, Ansgar W. Lohse, Stephan Becker, Marylyn M. Addo, Selidji Todagbe Agnandji, Sanjeev Krishna, Peter G. Kremsner, Jessica S. Brosnahan, Philip Bejon, Patricia Njuguna, Claire-Anne Siegrist, Angela Huttner, Marie-Paule Kieny, Kayvon Modjarrad, Vasee Moorthy, Patricia Fast, Barbara Savarese, Olivier Lapujade
Format:	Article
Language:	English
Published:	Elsevier 2017-05-01
Series:	EBioMedicine
Subjects:	rVSV-ZEBOV Ebola vaccine Phase I study T-cell responses Cytokines Humoral and cell-mediated immune responses
Online Access:	http://www.sciencedirect.com/science/article/pii/S235239641730141X

Similar Items

Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV
by: Anne Rechtien, et al.
Published: (2017-08-01)

Molecular characterisation of the recombinant Vesicular Stomatitis Virus- ZEBOV-GP virus, prototype vaccine against Ebola virus
by: Danet, Nicolas
Published: (2019)

Titration methods for rVSV-based vaccine manufacturing
by: Jean-François Gélinas, et al.
Published: (2020-01-01)

Being Pregnant during the Kivu Ebola Virus Outbreak in DR Congo: The rVSV-ZEBOV Vaccine and Its Accessibility by Mothers and Infants during Humanitarian Crises and in Conflict Areas
by: David A. Schwartz
Published: (2020-01-01)

Environmental Risk Assessment for rVSVΔG-ZEBOV-GP, a Genetically Modified Live Vaccine for Ebola Virus Disease
by: Joan G. Tell, et al.
Published: (2020-12-01)

Development of Pandemic Vaccines: ERVEBO Case Study
by: Jayanthi Wolf, et al.
Published: (2021-02-01)

To B or Not to B: Mechanisms of Protection Conferred by rVSV-EBOV-GP and the Roles of Innate and Adaptive Immunity
by: Amanda N. Pinski, et al.
Published: (2020-09-01)

Safety and immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccine in adults and children in Lambaréné, Gabon: A phase I randomised trial.
by: Selidji T Agnandji, et al.
Published: (2017-10-01)

Monitoring Group Activity of Hamsters and Mice as a Novel Tool to Evaluate COVID-19 Progression, Convalescence, and rVSV-ΔG-Spike Vaccination Efficacy
by: Sharon Melamed, et al.
Published: (2021-10-01)

Prior vaccination with rVSV-ZEBOV does not interfere with but improves efficacy of postexposure antibody treatment
by: Robert W. Cross, et al.
Published: (2020-07-01)

An update on the risk of transmission of Ebola virus (EBOV) via the food chain
by: European Food Safety Authority
Published: (2014-11-01)

Pseudovirus rVSVΔG-ZEBOV-GP Infects Neurons in Retina and CNS, Causing Apoptosis and Neurodegeneration in Neonatal Mice
by: Ian L. McWilliams, et al.
Published: (2019-02-01)

Human Transcriptomic Response to the VSV-Vectored Ebola Vaccine
by: Francesco Santoro, et al.
Published: (2021-01-01)

Comparing the efficacy and safety of potential clinical vaccines for the Ebola virus
by: Kim, Jason
Published: (2018)

Expression of a Large Single-Chain 13F6 Antibody with Binding Activity against Ebola Virus-Like Particles in a Plant System
by: Sohee Lim, et al.
Published: (2020-09-01)

Aufbau einer Apparatur zur Herstellung massenselektierter Nanopartikel: Inbetriebnahme und erste Anwendungen
by: Krähling, Stephan
Published: (2016)

Pregnancy Outcomes among Women Receiving rVSVΔ-ZEBOV-GP Ebola Vaccine during the Sierra Leone Trial to Introduce a Vaccine against Ebola
by: Jennifer K. Legardy-Williams, et al.
Published: (2020-03-01)

rVSVΔG-ZEBOV-GP (also designated V920) recombinant vesicular stomatitis virus pseudotyped with Ebola Zaire Glycoprotein: Standardized template with key considerations for a risk/benefit assessment
by: Thomas P. Monath, et al.
Published: (2019-04-01)

Serine-Arginine Protein Kinase 1 Regulates Ebola Virus Transcription
by: Yuki Takamatsu, et al.
Published: (2020-02-01)

Sex Differences in Immunity: Implications for the Development of Novel Vaccines Against Emerging Pathogens
by: Anahita Fathi, et al.
Published: (2021-01-01)

Establishment of fruit bat cells (Rousettus aegyptiacus) as a model system for the investigation of filoviral infection.
by: Verena Krähling, et al.
Published: (2010-01-01)

Electron tomography reveals the steps in filovirus budding.
by: Sonja Welsch, et al.
Published: (2010-04-01)

Ebola Outbreaks in the Democratic Republic of Congo (DRC), 2017-2019
by: Phi-Yen Nguyen
Published: (2019-06-01)

Professionalitätsentwicklung in der allgemeinen, öffentlichen Erwachsenenbildung für Inklusion – ein Systematisierungsversuch der Fortbildungspraxis an Volkshochschulen
by: Simone Krähling
Published: (2020-12-01)

A Dead-End Host: is there a way out? A position piece on the Ebola virus outbreak by the International Union of Immunology Societies
by: Clive M Gray, et al.
Published: (2014-10-01)

Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein <it>in-vitro </it>and <it>in-vivo</it>
by: Grywna Klaus, et al.
Published: (2009-08-01)

Developing Global Norms for Sharing Data and Results during Public Health Emergencies.
by: Kayvon Modjarrad, et al.
Published: (2016-01-01)

Cryo-electron tomography of Marburg virus particles and their morphogenesis within infected cells.
by: Tanmay A M Bharat, et al.
Published: (2011-11-01)

Correlates of Vaccine-Induced Protection against SARS-CoV-2
by: Till Koch, et al.
Published: (2021-03-01)

Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab
by: Mahir Karakas, et al.
Published: (2020-08-01)

Safety and immunogenicity of heterologous Ad26.ZEBOV and MVA-BN®-Filo prime-boost Ebola vaccines: 6-month follow-up of a Phase I randomized trial in healthy adults
by: Macaya Douoguih, et al.
Published: (2016-05-01)

Implicit theories of relationship: an intergenerational study
by: Lacey, Marylyn.
Published: (1976)

The coping strategies of adults aging with cerebral palsy
by: Horsman, Marylyn
Published: (2009)

The coping strategies of adults aging with cerebral palsy
by: Horsman, Marylyn
Published: (2009)

Hungry for a Serious Food Production Plan in the City of Vancouver
by: Chiang, Marylyn
Published: (2008)

A COMPARISON OF COAGULATION VALUES OBTAINED BY TRADITIONAL VENIPUNCTURE AND INTRA-ARTERIAL LINE METHODS IN ADULT PATIENTS.
by: Kajs, Marylyn.
Published: (1985)

The coping strategies of adults aging with cerebral palsy
by: Horsman, Marylyn
Published: (2009)

Transcriptomic analysis reveals a previously unknown role for CD8+ T-cells in rVSV-EBOV mediated protection
by: Andrea R. Menicucci, et al.
Published: (2017-04-01)

The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection
by: Gergely Imre, et al.
Published: (2021-04-01)

Single dose rVSVΔG-JUNVGP vaccine protects guinea pigs against lethal Junin virus challenge
by: Teresa E. Sorvillo, et al.
Published: (2021-08-01)