The influence of ABCG2 polymorphism on erlotinib efflux in the K562 cell line

The influence of ABCG2 polymorphism on erlotinib efflux in the K562 cell line

Abstract Single nucleotide polymorphisms (SNPs) in the gene for multidrug resistance protein ABCG2, an erlotinib transporter, is a possible contributor to the interindividual variation observed in erlotinib pharmacokinetics and toxicity. Therefore, the aim was to study erlotinib efflux by ABCG2 wild...

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Bibliographic Details
Main Authors: Anna Svedberg, Lianne Jacobs, Svante Vikingsson, Henrik Gréen
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Pharmacology Research & Perspectives
Subjects:
ABCG2
erlotinib
LC–MS/MS
polymorphism
transport
Online Access:https://doi.org/10.1002/prp2.581

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