Phylogenomic analyses and distribution of terpene synthases among Streptomyces
Terpene synthases are widely distributed among microorganisms and have been mainly studied in members of the genus Streptomyces. However, little is known about the distribution and evolution of the genes for terpene synthases. Here, we performed whole-genome based phylogenetic analysis of Streptomyc...
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doaj-d0dc856ee13c49e5a3d5051dc512d3f32021-03-02T09:14:54ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972019-05-011511181119310.3762/bjoc.15.1151860-5397-15-115Phylogenomic analyses and distribution of terpene synthases among StreptomycesLara Martín-Sánchez0Kumar Saurabh Singh1Mariana Avalos2Gilles P. van Wezel3Jeroen S. Dickschat4Paolina Garbeva5Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10, 6708 PB Wageningen, The NetherlandsCollege of Life and Environmental Sciences, Biosciences, University of Exeter, Penryn Campus, Penryn, Cornwall TR10 9FE, United KingdomDepartment of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10, 6708 PB Wageningen, The NetherlandsDepartment of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10, 6708 PB Wageningen, The NetherlandsDepartment of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10, 6708 PB Wageningen, The NetherlandsDepartment of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW), Droevendaalsesteeg 10, 6708 PB Wageningen, The NetherlandsTerpene synthases are widely distributed among microorganisms and have been mainly studied in members of the genus Streptomyces. However, little is known about the distribution and evolution of the genes for terpene synthases. Here, we performed whole-genome based phylogenetic analysis of Streptomyces species, and compared the distribution of terpene synthase genes among them. Overall, our study revealed that ten major types of terpene synthases are present within the genus Streptomyces, namely those for geosmin, 2-methylisoborneol, epi-isozizaene, 7-epi-α-eudesmol, epi-cubenol, caryolan-1-ol, cyclooctat-9-en-7-ol, isoafricanol, pentalenene and α-amorphene. The Streptomyces species divide in three phylogenetic groups based on their whole genomes for which the distribution of the ten terpene synthases was analysed. Geosmin synthases were the most widely distributed and were found to be evolutionary positively selected. Other terpene synthases were found to be specific for one of the three clades or a subclade within the genus Streptomyces. A phylogenetic analysis of the most widely distributed classes of Streptomyces terpene synthases in comparison to the phylogenomic analysis of this genus is discussed.https://doi.org/10.3762/bjoc.15.115biosynthesisevolutiongeosminStreptomycesterpenes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lara Martín-Sánchez Kumar Saurabh Singh Mariana Avalos Gilles P. van Wezel Jeroen S. Dickschat Paolina Garbeva |
spellingShingle |
Lara Martín-Sánchez Kumar Saurabh Singh Mariana Avalos Gilles P. van Wezel Jeroen S. Dickschat Paolina Garbeva Phylogenomic analyses and distribution of terpene synthases among Streptomyces Beilstein Journal of Organic Chemistry biosynthesis evolution geosmin Streptomyces terpenes |
author_facet |
Lara Martín-Sánchez Kumar Saurabh Singh Mariana Avalos Gilles P. van Wezel Jeroen S. Dickschat Paolina Garbeva |
author_sort |
Lara Martín-Sánchez |
title |
Phylogenomic analyses and distribution of terpene synthases among Streptomyces |
title_short |
Phylogenomic analyses and distribution of terpene synthases among Streptomyces |
title_full |
Phylogenomic analyses and distribution of terpene synthases among Streptomyces |
title_fullStr |
Phylogenomic analyses and distribution of terpene synthases among Streptomyces |
title_full_unstemmed |
Phylogenomic analyses and distribution of terpene synthases among Streptomyces |
title_sort |
phylogenomic analyses and distribution of terpene synthases among streptomyces |
publisher |
Beilstein-Institut |
series |
Beilstein Journal of Organic Chemistry |
issn |
1860-5397 |
publishDate |
2019-05-01 |
description |
Terpene synthases are widely distributed among microorganisms and have been mainly studied in members of the genus Streptomyces. However, little is known about the distribution and evolution of the genes for terpene synthases. Here, we performed whole-genome based phylogenetic analysis of Streptomyces species, and compared the distribution of terpene synthase genes among them. Overall, our study revealed that ten major types of terpene synthases are present within the genus Streptomyces, namely those for geosmin, 2-methylisoborneol, epi-isozizaene, 7-epi-α-eudesmol, epi-cubenol, caryolan-1-ol, cyclooctat-9-en-7-ol, isoafricanol, pentalenene and α-amorphene. The Streptomyces species divide in three phylogenetic groups based on their whole genomes for which the distribution of the ten terpene synthases was analysed. Geosmin synthases were the most widely distributed and were found to be evolutionary positively selected. Other terpene synthases were found to be specific for one of the three clades or a subclade within the genus Streptomyces. A phylogenetic analysis of the most widely distributed classes of Streptomyces terpene synthases in comparison to the phylogenomic analysis of this genus is discussed. |
topic |
biosynthesis evolution geosmin Streptomyces terpenes |
url |
https://doi.org/10.3762/bjoc.15.115 |
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