The Full Blood Count Blood Test for Colorectal Cancer Detection: A Systematic Review, Meta-Analysis, and Critical Appraisal
Introduction: A full blood count (FBC) blood test includes 20 components. We systematically reviewed studies that assessed the association of the FBC and diagnosis of colorectal cancer to identify components as risk factors. We reviewed FBC-based prediction models for colorectal cancer risk. Methods...
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doaj-d0e39430be2247ad867dcb2fe7794bcb2020-11-25T03:41:20ZengMDPI AGCancers2072-66942020-08-01122348234810.3390/cancers12092348The Full Blood Count Blood Test for Colorectal Cancer Detection: A Systematic Review, Meta-Analysis, and Critical AppraisalPradeep S. Virdee0Ioana R. Marian1Anita Mansouri2Leena Elhussein3Shona Kirtley4Tim Holt5Jacqueline Birks6Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UKCentre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UKCentre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UKCentre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UKCentre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UKNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford OX2 6GG, UKCentre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UKIntroduction: A full blood count (FBC) blood test includes 20 components. We systematically reviewed studies that assessed the association of the FBC and diagnosis of colorectal cancer to identify components as risk factors. We reviewed FBC-based prediction models for colorectal cancer risk. Methods: MEDLINE, EMBASE, CINAHL, and Web of Science were searched until 3 September 2019. We meta-analysed the mean difference in FBC components between those with and without a diagnosis and critically appraised the development and validation of FBC-based prediction models. Results: We included 53 eligible articles. Three of four meta-analysed components showed an association with diagnosis. In the remaining 16 with insufficient data for meta-analysis, three were associated with colorectal cancer. Thirteen FBC-based models were developed. Model performance was commonly assessed using the c-statistic (range 0.72–0.91) and calibration plots. Some models appeared to work well for early detection but good performance may be driven by early events. Conclusion: Red blood cells, haemoglobin, mean corpuscular volume, red blood cell distribution width, white blood cell count, and platelets are associated with diagnosis and could be used for referral. Existing FBC-based prediction models might not perform as well as expected and need further critical testing.https://www.mdpi.com/2072-6694/12/9/2348full blood countcomplete blood countblood testcolorectal cancerbowel cancersystematic |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pradeep S. Virdee Ioana R. Marian Anita Mansouri Leena Elhussein Shona Kirtley Tim Holt Jacqueline Birks |
spellingShingle |
Pradeep S. Virdee Ioana R. Marian Anita Mansouri Leena Elhussein Shona Kirtley Tim Holt Jacqueline Birks The Full Blood Count Blood Test for Colorectal Cancer Detection: A Systematic Review, Meta-Analysis, and Critical Appraisal Cancers full blood count complete blood count blood test colorectal cancer bowel cancer systematic |
author_facet |
Pradeep S. Virdee Ioana R. Marian Anita Mansouri Leena Elhussein Shona Kirtley Tim Holt Jacqueline Birks |
author_sort |
Pradeep S. Virdee |
title |
The Full Blood Count Blood Test for Colorectal Cancer Detection: A Systematic Review, Meta-Analysis, and Critical Appraisal |
title_short |
The Full Blood Count Blood Test for Colorectal Cancer Detection: A Systematic Review, Meta-Analysis, and Critical Appraisal |
title_full |
The Full Blood Count Blood Test for Colorectal Cancer Detection: A Systematic Review, Meta-Analysis, and Critical Appraisal |
title_fullStr |
The Full Blood Count Blood Test for Colorectal Cancer Detection: A Systematic Review, Meta-Analysis, and Critical Appraisal |
title_full_unstemmed |
The Full Blood Count Blood Test for Colorectal Cancer Detection: A Systematic Review, Meta-Analysis, and Critical Appraisal |
title_sort |
full blood count blood test for colorectal cancer detection: a systematic review, meta-analysis, and critical appraisal |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-08-01 |
description |
Introduction: A full blood count (FBC) blood test includes 20 components. We systematically reviewed studies that assessed the association of the FBC and diagnosis of colorectal cancer to identify components as risk factors. We reviewed FBC-based prediction models for colorectal cancer risk. Methods: MEDLINE, EMBASE, CINAHL, and Web of Science were searched until 3 September 2019. We meta-analysed the mean difference in FBC components between those with and without a diagnosis and critically appraised the development and validation of FBC-based prediction models. Results: We included 53 eligible articles. Three of four meta-analysed components showed an association with diagnosis. In the remaining 16 with insufficient data for meta-analysis, three were associated with colorectal cancer. Thirteen FBC-based models were developed. Model performance was commonly assessed using the c-statistic (range 0.72–0.91) and calibration plots. Some models appeared to work well for early detection but good performance may be driven by early events. Conclusion: Red blood cells, haemoglobin, mean corpuscular volume, red blood cell distribution width, white blood cell count, and platelets are associated with diagnosis and could be used for referral. Existing FBC-based prediction models might not perform as well as expected and need further critical testing. |
topic |
full blood count complete blood count blood test colorectal cancer bowel cancer systematic |
url |
https://www.mdpi.com/2072-6694/12/9/2348 |
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