Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative Medicine

Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative Medicine

Mesenchymal stem cells are a promising source for externally grown tissue replacements and patient-specific immunomodulatory treatments. This promise has not yet been fulfilled in part due to production scaling issues and the need to maintain the correct phenotype after re-implantation. One aspect o...

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Bibliographic Details
Main Authors: Þóra Sigmarsdóttir, Sarah McGarrity, Óttar Rolfsson, James T. Yurkovich, Ólafur E. Sigurjónsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
MSCs
metabolism
personalized/precision medicine
metabolomics
metabolic modeling
tissue engineering
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00239/full

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