Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes

Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes

EMR2/ADGRE2 is an adhesion G protein-coupled receptor differentially expressed by human myeloid cells. It modulates diverse cellular functions of innate immune cells and a missense EMR2 variant is directly responsible for vibratory urticaria. Recently, EMR2 was found to activate NLRP3 inflammasome i...

Full description

Bibliographic Details
Main Authors: Kuan-Yu I, Wen-Yi Tseng, Wen-Chih Wang, Siamon Gordon, Kwai-Fong Ng, Hsi-Hsien Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
adhesion G protein-coupled receptor
inflammasome
NLRP3
signaling
pathogen-associated molecular patterns
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.602016/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.602016/full

Similar Items