Human papillomavirus infection and cervical cancer in Brazil: a retrospective study
Two hundred and thirty paraffin-embedded biopsies obtained from female cervical lesions were tested for the presence of human papillomavirus (HPV) types 6/11,16/18 and 31/33/35 DNA using non-isotopic in situ hybridization. Specimens were classified according to the Bethesda System in low grade squam...
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Instituto Oswaldo Cruz, Ministério da Saúde
1996-08-01
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doaj-d1252e76752246d6b22239f44306ef472020-11-24T23:40:44ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.0074-02761678-80601996-08-0191443344010.1590/S0074-02761996000400009Human papillomavirus infection and cervical cancer in Brazil: a retrospective studySílvia MB CavalcantiFlávia CC DeusLucília G ZardoIzabel CPP FrugulhettiLedy HS OliveiraTwo hundred and thirty paraffin-embedded biopsies obtained from female cervical lesions were tested for the presence of human papillomavirus (HPV) types 6/11,16/18 and 31/33/35 DNA using non-isotopic in situ hybridization. Specimens were classified according to the Bethesda System in low grade squamous intraepithelial lesion (LSIL), high grade SIL (HSIL) and squamous cell carcinoma (SCC). HPV prevalence ranged from 92.5% in LSIL to 68.5% in SCC. Benign types were prevalent in LSILs while oncogenic types infected predominantly HSILs and SCC. HPV infection showed to be age-dependent, but no significant relation to race has been detected. Patients were analyzed through a five-year period: 20.7% of the lesions spontaneously regressed while 48.9% persisted and 30.4% progressed to carcinoma. Patients submitted to treatment showed a 19.4% recurrence rate. High risk types were present in 78.6% (CrudeOR 13.8, P=0.0003) of the progressive lesions, and in 73.7% of the recurrent SILs (COR 19.3, P=0.0000001). Possible co-factors have also been evaluated: history of other sexually transmitted diseases showed to be positively related either to progression (Adjusted OR 13.0, P=0.0002) or to recurrence (AOR 17.2, P=0.0002) while oral contraceptive use and tobacco smoking were not significantly related to them (P>0.1). Association of two or more co-factors also proved to be related to both progression and recurrence, indicating that they may interact with HPV infection in order to increase the risk of developing malignant lesions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761996000400009human papillomavirusprogressionrisk factorscervical cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sílvia MB Cavalcanti Flávia CC Deus Lucília G Zardo Izabel CPP Frugulhetti Ledy HS Oliveira |
spellingShingle |
Sílvia MB Cavalcanti Flávia CC Deus Lucília G Zardo Izabel CPP Frugulhetti Ledy HS Oliveira Human papillomavirus infection and cervical cancer in Brazil: a retrospective study Memórias do Instituto Oswaldo Cruz. human papillomavirus progression risk factors cervical cancer |
author_facet |
Sílvia MB Cavalcanti Flávia CC Deus Lucília G Zardo Izabel CPP Frugulhetti Ledy HS Oliveira |
author_sort |
Sílvia MB Cavalcanti |
title |
Human papillomavirus infection and cervical cancer in Brazil: a retrospective study |
title_short |
Human papillomavirus infection and cervical cancer in Brazil: a retrospective study |
title_full |
Human papillomavirus infection and cervical cancer in Brazil: a retrospective study |
title_fullStr |
Human papillomavirus infection and cervical cancer in Brazil: a retrospective study |
title_full_unstemmed |
Human papillomavirus infection and cervical cancer in Brazil: a retrospective study |
title_sort |
human papillomavirus infection and cervical cancer in brazil: a retrospective study |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
series |
Memórias do Instituto Oswaldo Cruz. |
issn |
0074-0276 1678-8060 |
publishDate |
1996-08-01 |
description |
Two hundred and thirty paraffin-embedded biopsies obtained from female cervical lesions were tested for the presence of human papillomavirus (HPV) types 6/11,16/18 and 31/33/35 DNA using non-isotopic in situ hybridization. Specimens were classified according to the Bethesda System in low grade squamous intraepithelial lesion (LSIL), high grade SIL (HSIL) and squamous cell carcinoma (SCC). HPV prevalence ranged from 92.5% in LSIL to 68.5% in SCC. Benign types were prevalent in LSILs while oncogenic types infected predominantly HSILs and SCC. HPV infection showed to be age-dependent, but no significant relation to race has been detected. Patients were analyzed through a five-year period: 20.7% of the lesions spontaneously regressed while 48.9% persisted and 30.4% progressed to carcinoma. Patients submitted to treatment showed a 19.4% recurrence rate. High risk types were present in 78.6% (CrudeOR 13.8, P=0.0003) of the progressive lesions, and in 73.7% of the recurrent SILs (COR 19.3, P=0.0000001). Possible co-factors have also been evaluated: history of other sexually transmitted diseases showed to be positively related either to progression (Adjusted OR 13.0, P=0.0002) or to recurrence (AOR 17.2, P=0.0002) while oral contraceptive use and tobacco smoking were not significantly related to them (P>0.1). Association of two or more co-factors also proved to be related to both progression and recurrence, indicating that they may interact with HPV infection in order to increase the risk of developing malignant lesions. |
topic |
human papillomavirus progression risk factors cervical cancer |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761996000400009 |
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