ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia.
Current antiretroviral therapy is effective in suppressing but not eliminating HIV-1 infection. Understanding the source of viral persistence is essential for developing strategies to eradicate HIV-1 infection. We therefore investigated the level of plasma HIV-1 RNA in patients with viremia suppress...
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2007-04-01
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doaj-d12783e8e17c4822bde2560ae3f5522f2020-11-25T00:57:37ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742007-04-0134e4610.1371/journal.ppat.0030046ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia.Frank MaldarelliSarah PalmerMartin S KingAnn WiegandMichael A PolisJoAnn MicanJoseph A KovacsRichard T DaveyDiane Rock-KressRobin DewarShuying LiuJulia A MetcalfCatherine RehmScott C BrunGeorge J HannaDale J KempfJohn M CoffinJohn W MellorsCurrent antiretroviral therapy is effective in suppressing but not eliminating HIV-1 infection. Understanding the source of viral persistence is essential for developing strategies to eradicate HIV-1 infection. We therefore investigated the level of plasma HIV-1 RNA in patients with viremia suppressed to less than 50-75 copies/ml on standard protease inhibitor- or non-nucleoside reverse transcriptase inhibitor-containing antiretroviral therapy using a new, real-time PCR-based assay for HIV-1 RNA with a limit of detection of one copy of HIV-1 RNA. Single copy assay results revealed that >80% of patients on initial antiretroviral therapy for 60 wk had persistent viremia of one copy/ml or more with an overall median of 3.1 copies/ml. The level of viremia correlated with pretherapy plasma HIV-1 RNA but not with the specific treatment regimen. Longitudinal studies revealed no significant decline in the level of viremia between 60 and 110 wk of suppressive antiretroviral therapy. These data suggest that the persistent viremia on current antiretroviral therapy is derived, at least in part, from long-lived cells that are infected prior to initiation of therapy.http://europepmc.org/articles/PMC1847689?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Frank Maldarelli Sarah Palmer Martin S King Ann Wiegand Michael A Polis JoAnn Mican Joseph A Kovacs Richard T Davey Diane Rock-Kress Robin Dewar Shuying Liu Julia A Metcalf Catherine Rehm Scott C Brun George J Hanna Dale J Kempf John M Coffin John W Mellors |
spellingShingle |
Frank Maldarelli Sarah Palmer Martin S King Ann Wiegand Michael A Polis JoAnn Mican Joseph A Kovacs Richard T Davey Diane Rock-Kress Robin Dewar Shuying Liu Julia A Metcalf Catherine Rehm Scott C Brun George J Hanna Dale J Kempf John M Coffin John W Mellors ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. PLoS Pathogens |
author_facet |
Frank Maldarelli Sarah Palmer Martin S King Ann Wiegand Michael A Polis JoAnn Mican Joseph A Kovacs Richard T Davey Diane Rock-Kress Robin Dewar Shuying Liu Julia A Metcalf Catherine Rehm Scott C Brun George J Hanna Dale J Kempf John M Coffin John W Mellors |
author_sort |
Frank Maldarelli |
title |
ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. |
title_short |
ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. |
title_full |
ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. |
title_fullStr |
ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. |
title_full_unstemmed |
ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. |
title_sort |
art suppresses plasma hiv-1 rna to a stable set point predicted by pretherapy viremia. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Pathogens |
issn |
1553-7366 1553-7374 |
publishDate |
2007-04-01 |
description |
Current antiretroviral therapy is effective in suppressing but not eliminating HIV-1 infection. Understanding the source of viral persistence is essential for developing strategies to eradicate HIV-1 infection. We therefore investigated the level of plasma HIV-1 RNA in patients with viremia suppressed to less than 50-75 copies/ml on standard protease inhibitor- or non-nucleoside reverse transcriptase inhibitor-containing antiretroviral therapy using a new, real-time PCR-based assay for HIV-1 RNA with a limit of detection of one copy of HIV-1 RNA. Single copy assay results revealed that >80% of patients on initial antiretroviral therapy for 60 wk had persistent viremia of one copy/ml or more with an overall median of 3.1 copies/ml. The level of viremia correlated with pretherapy plasma HIV-1 RNA but not with the specific treatment regimen. Longitudinal studies revealed no significant decline in the level of viremia between 60 and 110 wk of suppressive antiretroviral therapy. These data suggest that the persistent viremia on current antiretroviral therapy is derived, at least in part, from long-lived cells that are infected prior to initiation of therapy. |
url |
http://europepmc.org/articles/PMC1847689?pdf=render |
work_keys_str_mv |
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