Predictive relevance of lymphovascular invasion in T1 colorectal cancer before endoscopic treatment
Background and aim The depth of tumor invasion is currently the only reliable predictive risk factor for lymph node metastasis before endoscopic treatment for colorectal cancer. However, the most important factor to predict lymph node metastasis has been suggested to be lymphovascular invasion rathe...
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doaj-d12ba0fabe124de3badd13ddb4136a102020-11-25T02:31:40ZengGeorg Thieme Verlag KGEndoscopy International Open2364-37222196-97362017-12-010512E1278E128310.1055/s-0043-117952Predictive relevance of lymphovascular invasion in T1 colorectal cancer before endoscopic treatmentKazuya Inoki0Taku Sakamoto1Hiroyuki Takamaru2Masau Sekiguchi3Masayoshi Yamada4Takeshi Nakajima5Takahisa Matsuda6Hirokazu Taniguchi7Shigeki Sekine8Yukihide Kanemitsu9Yuichiro Ohe10Yutaka Saito11Endoscopy Division, National Cancer Center Hospital, Tokyo, JapanEndoscopy Division, National Cancer Center Hospital, Tokyo, JapanEndoscopy Division, National Cancer Center Hospital, Tokyo, JapanEndoscopy Division, National Cancer Center Hospital, Tokyo, JapanEndoscopy Division, National Cancer Center Hospital, Tokyo, JapanEndoscopy Division, National Cancer Center Hospital, Tokyo, JapanEndoscopy Division, National Cancer Center Hospital, Tokyo, JapanPathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, JapanPathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, JapanColorectal Surgery Division, National Cancer Center Hospital, Tokyo, JapanCourse of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, National Cancer Center Hospital, Tokyo, JapanEndoscopy Division, National Cancer Center Hospital, Tokyo, JapanBackground and aim The depth of tumor invasion is currently the only reliable predictive risk factor for lymph node metastasis before endoscopic treatment for colorectal cancer. However, the most important factor to predict lymph node metastasis has been suggested to be lymphovascular invasion rather than the depth of invasion. Thus, the aim of this study was to investigate the predictive relevance of lymphovascular invasion before endoscopic treatment. Methods The data on pT1 colorectal cancers that were resected endoscopically or surgically from 2007 to 2015 were retrospectively reviewed. The cases were categorized into two groups: positive or negative for lymphovascular invasion. The following factors were evaluated by univariate and multivariate analyses: age and sex of the patients; location, size, and morphology of the lesion; and depth of invasion. Results The positive and negative groups included 229 and 457 cases, respectively. Younger age (P < 0.01), smaller lesion size (P = 0.01), non-LST (LST: laterally spreading tumor) (P < 0.01), presence of depression (P < 0.01), and pT1b (P < 0.01) were associated with lymphovascular invasion. In multivariate analysis, younger age (comparing patients aged ≤ 64 years with those aged > 65 years, OR, 1.81; 95 %CI, 1.29 – 2.53), presence of depression (OR, 1.97; CI, 1.40 – 2.77), non-LST features (OR, 1.50; CI, 1.04 – 2.15), and pT1b (OR, 3.08; CI, 1.91 – 4.97) were associated with lymphovascular invasion. Conclusion Younger age, presence of depression, T1b, and non-LST are associated with lymphovascular invasion. Therefore, careful pathological diagnosis and surveillance are necessary for lesions demonstrating any of these four factors.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-117952 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kazuya Inoki Taku Sakamoto Hiroyuki Takamaru Masau Sekiguchi Masayoshi Yamada Takeshi Nakajima Takahisa Matsuda Hirokazu Taniguchi Shigeki Sekine Yukihide Kanemitsu Yuichiro Ohe Yutaka Saito |
spellingShingle |
Kazuya Inoki Taku Sakamoto Hiroyuki Takamaru Masau Sekiguchi Masayoshi Yamada Takeshi Nakajima Takahisa Matsuda Hirokazu Taniguchi Shigeki Sekine Yukihide Kanemitsu Yuichiro Ohe Yutaka Saito Predictive relevance of lymphovascular invasion in T1 colorectal cancer before endoscopic treatment Endoscopy International Open |
author_facet |
Kazuya Inoki Taku Sakamoto Hiroyuki Takamaru Masau Sekiguchi Masayoshi Yamada Takeshi Nakajima Takahisa Matsuda Hirokazu Taniguchi Shigeki Sekine Yukihide Kanemitsu Yuichiro Ohe Yutaka Saito |
author_sort |
Kazuya Inoki |
title |
Predictive relevance of lymphovascular invasion in T1 colorectal cancer before endoscopic treatment |
title_short |
Predictive relevance of lymphovascular invasion in T1 colorectal cancer before endoscopic treatment |
title_full |
Predictive relevance of lymphovascular invasion in T1 colorectal cancer before endoscopic treatment |
title_fullStr |
Predictive relevance of lymphovascular invasion in T1 colorectal cancer before endoscopic treatment |
title_full_unstemmed |
Predictive relevance of lymphovascular invasion in T1 colorectal cancer before endoscopic treatment |
title_sort |
predictive relevance of lymphovascular invasion in t1 colorectal cancer before endoscopic treatment |
publisher |
Georg Thieme Verlag KG |
series |
Endoscopy International Open |
issn |
2364-3722 2196-9736 |
publishDate |
2017-12-01 |
description |
Background and aim The depth of tumor invasion is currently the only reliable predictive risk factor for lymph node metastasis before endoscopic treatment for colorectal cancer. However, the most important factor to predict lymph node metastasis has been suggested to be lymphovascular invasion rather than the depth of invasion. Thus, the aim of this study was to investigate the predictive relevance of lymphovascular invasion before endoscopic treatment.
Methods The data on pT1 colorectal cancers that were resected endoscopically or surgically from 2007 to 2015 were retrospectively reviewed. The cases were categorized into two groups: positive or negative for lymphovascular invasion. The following factors were evaluated by univariate and multivariate analyses: age and sex of the patients; location, size, and morphology of the lesion; and depth of invasion.
Results The positive and negative groups included 229 and 457 cases, respectively. Younger age (P < 0.01), smaller lesion size (P = 0.01), non-LST (LST: laterally spreading tumor) (P < 0.01), presence of depression (P < 0.01), and pT1b (P < 0.01) were associated with lymphovascular invasion. In multivariate analysis, younger age (comparing patients aged ≤ 64 years with those aged > 65 years, OR, 1.81; 95 %CI, 1.29 – 2.53), presence of depression (OR, 1.97; CI, 1.40 – 2.77), non-LST features (OR, 1.50; CI, 1.04 – 2.15), and pT1b (OR, 3.08; CI, 1.91 – 4.97) were associated with lymphovascular invasion.
Conclusion Younger age, presence of depression, T1b, and non-LST are associated with lymphovascular invasion. Therefore, careful pathological diagnosis and surveillance are necessary for lesions demonstrating any of these four factors. |
url |
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-117952 |
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