A Mycobacterium avium subsp. paratuberculosis relA deletion mutant and a 35 kDa major membrane protein elicit development of cytotoxic T lymphocytes with ability to kill intracellular bacteria

A Mycobacterium avium subsp. paratuberculosis relA deletion mutant and a 35 kDa major membrane protein elicit development of cytotoxic T lymphocytes with ability to kill intracellular bacteria

Abstract Efforts to develop live attenuated vaccines against Mycobacterium avium subspecies paratuberculosis (Map), using indirect methods to screen Map deletion mutants for potential efficacy, have not been successful. A reduction in the capacity to survive in macrophages has not predicted the abil...

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Bibliographic Details
Main Authors: Gaber S. Abdellrazeq, Mahmoud M. Elnaggar, John P. Bannantine, Kun T. Park, Cleverson D. Souza, Brian Backer, Victoria Hulubei, Lindsay M. Fry, Samy A. Khaliel, Helmy A. Torky, David A. Schneider, William C. Davis
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Veterinary Research
Online Access:http://link.springer.com/article/10.1186/s13567-018-0549-3

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