Lung Macrophage Phenotypes and Functional Responses: Role in the Pathogenesis of COPD
Lung macrophages (LMs) are essential immune effector cells that are pivotal in both innate and adaptive immune responses to inhaled foreign matter. They either reside within the airways and lung tissues (from early life) or are derived from blood monocytes. Similar to macrophages in other organs and...
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doaj-d130008f4bde4e8f847d9711931eda122020-11-25T00:55:09ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-02-0119258210.3390/ijms19020582ijms19020582Lung Macrophage Phenotypes and Functional Responses: Role in the Pathogenesis of COPDKei Yamasaki0Stephan F. van Eeden1Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, BC V6Z1Y6, CanadaCentre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, BC V6Z1Y6, CanadaLung macrophages (LMs) are essential immune effector cells that are pivotal in both innate and adaptive immune responses to inhaled foreign matter. They either reside within the airways and lung tissues (from early life) or are derived from blood monocytes. Similar to macrophages in other organs and tissues, LMs have natural plasticity and can change phenotype and function depending largely on the microenvironment they reside in. Phenotype changes in lung tissue macrophages have been implicated in chronic inflammatory responses and disease progression of various chronic lung diseases, including Chronic Obstructive Pulmonary Disease (COPD). LMs have a wide variety of functional properties that include phagocytosis (inorganic particulate matter and organic particles, such as viruses/bacteria/fungi), the processing of phagocytosed material, and the production of signaling mediators. Functioning as janitors of the airways, they also play a key role in removing dead and dying cells, as well as cell debris (efferocytic functions). We herein review changes in LM phenotypes during chronic lung disease, focusing on COPD, as well as changes in their functional properties as a result of such shifts. Targeting molecular pathways involved in LM phenotypic shifts could potentially allow for future targeted therapeutic interventions in several diseases, such as COPD.http://www.mdpi.com/1422-0067/19/2/582lung macrophage phenotypeschronic obstructive pulmonary diseasephagocytic function of macrophage |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kei Yamasaki Stephan F. van Eeden |
spellingShingle |
Kei Yamasaki Stephan F. van Eeden Lung Macrophage Phenotypes and Functional Responses: Role in the Pathogenesis of COPD International Journal of Molecular Sciences lung macrophage phenotypes chronic obstructive pulmonary disease phagocytic function of macrophage |
author_facet |
Kei Yamasaki Stephan F. van Eeden |
author_sort |
Kei Yamasaki |
title |
Lung Macrophage Phenotypes and Functional Responses: Role in the Pathogenesis of COPD |
title_short |
Lung Macrophage Phenotypes and Functional Responses: Role in the Pathogenesis of COPD |
title_full |
Lung Macrophage Phenotypes and Functional Responses: Role in the Pathogenesis of COPD |
title_fullStr |
Lung Macrophage Phenotypes and Functional Responses: Role in the Pathogenesis of COPD |
title_full_unstemmed |
Lung Macrophage Phenotypes and Functional Responses: Role in the Pathogenesis of COPD |
title_sort |
lung macrophage phenotypes and functional responses: role in the pathogenesis of copd |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-02-01 |
description |
Lung macrophages (LMs) are essential immune effector cells that are pivotal in both innate and adaptive immune responses to inhaled foreign matter. They either reside within the airways and lung tissues (from early life) or are derived from blood monocytes. Similar to macrophages in other organs and tissues, LMs have natural plasticity and can change phenotype and function depending largely on the microenvironment they reside in. Phenotype changes in lung tissue macrophages have been implicated in chronic inflammatory responses and disease progression of various chronic lung diseases, including Chronic Obstructive Pulmonary Disease (COPD). LMs have a wide variety of functional properties that include phagocytosis (inorganic particulate matter and organic particles, such as viruses/bacteria/fungi), the processing of phagocytosed material, and the production of signaling mediators. Functioning as janitors of the airways, they also play a key role in removing dead and dying cells, as well as cell debris (efferocytic functions). We herein review changes in LM phenotypes during chronic lung disease, focusing on COPD, as well as changes in their functional properties as a result of such shifts. Targeting molecular pathways involved in LM phenotypic shifts could potentially allow for future targeted therapeutic interventions in several diseases, such as COPD. |
topic |
lung macrophage phenotypes chronic obstructive pulmonary disease phagocytic function of macrophage |
url |
http://www.mdpi.com/1422-0067/19/2/582 |
work_keys_str_mv |
AT keiyamasaki lungmacrophagephenotypesandfunctionalresponsesroleinthepathogenesisofcopd AT stephanfvaneeden lungmacrophagephenotypesandfunctionalresponsesroleinthepathogenesisofcopd |
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