A novel BMI-1 inhibitor QW24 for the treatment of stem-like colorectal cancer

A novel BMI-1 inhibitor QW24 for the treatment of stem-like colorectal cancer

Abstract Background Cancer-initiating cell (CIC), a functionally homogeneous stem-like cell population, is resonsible for driving the tumor maintenance and metastasis, and is a source of chemotherapy and radiation-therapy resistance within tumors. Targeting CICs self-renewal has been proposed as a t...

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Bibliographic Details
Main Authors: Jinhua Wang, Yajing Xing, Yingying Wang, Yundong He, Liting Wang, Shihong Peng, Lianfang Yang, Jiuqing Xie, Xiaotao Li, Wenwei Qiu, Zhengfang Yi, Mingyao Liu
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer
Cancer stem-like
BMI-1
Online Access:http://link.springer.com/article/10.1186/s13046-019-1392-8

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