Neurotoxicity of Pneumolysin, a Major Pneumococcal Virulence Factor, Involves Calcium Influx and Depends on Activation of p38 Mitogen-Activated Protein Kinase

Neurotoxicity of Pneumolysin, a Major Pneumococcal Virulence Factor, Involves Calcium Influx and Depends on Activation of p38 Mitogen-Activated Protein Kinase

Neuronal injury in bacterial meningitis is caused by the interplay of host inflammatory responses and direct bacterial toxicity. We investigated the mechanisms by which pneumolysin, a cytosolic pneumococcal protein, induces damage to neurons. The toxicity after exposure of human SH-SY5Y neuroblastom...

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Bibliographic Details
Main Authors: Argyrios K. Stringaris, Jens Geisenhainer, Friederike Bergmann, Christoph Balshüsemann, Unaa Lee, Gregor Zysk, Timothy J. Mitchell, Bernhard U. Keller, Ulrich Kuhnt, Joachim Gerber, Annette Spreer, Mathias Bähr, Uwe Michel, Roland Nau
Format: Article
Language:English
Published: Elsevier 2002-12-01
Series:Neurobiology of Disease
Subjects:
pneumolysin
p38 mitogen-activated protein kinase
calcium
meningitis
apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905619

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http://www.sciencedirect.com/science/article/pii/S0969996102905619

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