Antipsychotic prescribing for Alzheimer’s disease and related disorders in specialized settings from 2010 to 2014 in France: a repeated cross-sectional study
Abstract Background Safety warnings from health authorities are currently intended to limit the use of antipsychotics (APs) in dementia-related conditions to treat neuropsychiatric symptoms, such as disturbing and/or delusional behaviors. The aim of this study is to investigate prevalence, correlate...
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doaj-d15feeff46d5425a8b56632a5a928ae22020-11-25T00:46:08ZengBMCAlzheimer’s Research & Therapy1758-91932017-04-019111010.1186/s13195-017-0256-8Antipsychotic prescribing for Alzheimer’s disease and related disorders in specialized settings from 2010 to 2014 in France: a repeated cross-sectional studyKarim Tifratene0Valeria Manera1Roxane Fabre2Auriane Gros3Susanne Thummler4Christian Pradier5Philippe Robert6Renaud David7EA Cobtek, University of Nice Sophia-AntipolisEA Cobtek, University of Nice Sophia-AntipolisEA Cobtek, University of Nice Sophia-AntipolisEA Cobtek, University of Nice Sophia-AntipolisEA Cobtek, University of Nice Sophia-AntipolisDepartment of Public Health, L’Archet Hospital, Nice University HospitalEA Cobtek, University of Nice Sophia-AntipolisEA Cobtek, University of Nice Sophia-AntipolisAbstract Background Safety warnings from health authorities are currently intended to limit the use of antipsychotics (APs) in dementia-related conditions to treat neuropsychiatric symptoms, such as disturbing and/or delusional behaviors. The aim of this study is to investigate prevalence, correlates and trends of AP prescribing among people with dementia between 2010 and 2014 in the French population. Methods AP prescribing and associated factors among individuals with AD, mixed dementia and vascular dementia in the French National Alzheimer Database between 2010 and 2014 were analyzed using multivariate generalized estimating equations models (n = 199,549). Results In 2014, 7.7% of people with dementia were prescribed an AP. Compared with 2010 there was a 16% increase in AP use. Multivariate analysis showed a linear increase risk of prescription with an adjusted odds ratio (95% confidence interval) of 1.23 (1.17–1.30) in 2014 compared with 2010. Factors associated with AP prescribing were male gender, more severe cognitive decline and living in long-term care facilities. Older age and higher education were protective toward AP prescribing. The type of dementia did not have any influence on AP prescribing. Conclusion An increase in AP prescribing among individuals with dementia in French specialized settings over the last 5 years occurred despite safety warnings. This phenomenon suggests that alternative solutions for the management of behavioral and psychiatric symptoms in these populations are still urgently needed.http://link.springer.com/article/10.1186/s13195-017-0256-8DementiaAlzheimer’s diseaseAntipsychoticsDrug prescribingFrench Alzheimer Database |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karim Tifratene Valeria Manera Roxane Fabre Auriane Gros Susanne Thummler Christian Pradier Philippe Robert Renaud David |
spellingShingle |
Karim Tifratene Valeria Manera Roxane Fabre Auriane Gros Susanne Thummler Christian Pradier Philippe Robert Renaud David Antipsychotic prescribing for Alzheimer’s disease and related disorders in specialized settings from 2010 to 2014 in France: a repeated cross-sectional study Alzheimer’s Research & Therapy Dementia Alzheimer’s disease Antipsychotics Drug prescribing French Alzheimer Database |
author_facet |
Karim Tifratene Valeria Manera Roxane Fabre Auriane Gros Susanne Thummler Christian Pradier Philippe Robert Renaud David |
author_sort |
Karim Tifratene |
title |
Antipsychotic prescribing for Alzheimer’s disease and related disorders in specialized settings from 2010 to 2014 in France: a repeated cross-sectional study |
title_short |
Antipsychotic prescribing for Alzheimer’s disease and related disorders in specialized settings from 2010 to 2014 in France: a repeated cross-sectional study |
title_full |
Antipsychotic prescribing for Alzheimer’s disease and related disorders in specialized settings from 2010 to 2014 in France: a repeated cross-sectional study |
title_fullStr |
Antipsychotic prescribing for Alzheimer’s disease and related disorders in specialized settings from 2010 to 2014 in France: a repeated cross-sectional study |
title_full_unstemmed |
Antipsychotic prescribing for Alzheimer’s disease and related disorders in specialized settings from 2010 to 2014 in France: a repeated cross-sectional study |
title_sort |
antipsychotic prescribing for alzheimer’s disease and related disorders in specialized settings from 2010 to 2014 in france: a repeated cross-sectional study |
publisher |
BMC |
series |
Alzheimer’s Research & Therapy |
issn |
1758-9193 |
publishDate |
2017-04-01 |
description |
Abstract Background Safety warnings from health authorities are currently intended to limit the use of antipsychotics (APs) in dementia-related conditions to treat neuropsychiatric symptoms, such as disturbing and/or delusional behaviors. The aim of this study is to investigate prevalence, correlates and trends of AP prescribing among people with dementia between 2010 and 2014 in the French population. Methods AP prescribing and associated factors among individuals with AD, mixed dementia and vascular dementia in the French National Alzheimer Database between 2010 and 2014 were analyzed using multivariate generalized estimating equations models (n = 199,549). Results In 2014, 7.7% of people with dementia were prescribed an AP. Compared with 2010 there was a 16% increase in AP use. Multivariate analysis showed a linear increase risk of prescription with an adjusted odds ratio (95% confidence interval) of 1.23 (1.17–1.30) in 2014 compared with 2010. Factors associated with AP prescribing were male gender, more severe cognitive decline and living in long-term care facilities. Older age and higher education were protective toward AP prescribing. The type of dementia did not have any influence on AP prescribing. Conclusion An increase in AP prescribing among individuals with dementia in French specialized settings over the last 5 years occurred despite safety warnings. This phenomenon suggests that alternative solutions for the management of behavioral and psychiatric symptoms in these populations are still urgently needed. |
topic |
Dementia Alzheimer’s disease Antipsychotics Drug prescribing French Alzheimer Database |
url |
http://link.springer.com/article/10.1186/s13195-017-0256-8 |
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