Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy.
The bone marrow microenvironment plays an important role in acute lymphoblastic leukemia (ALL) cell proliferation, maintenance, and resistance to chemotherapy. Annexin II (ANX2) is abundantly expressed on bone marrow cells and complexes with p11 to form ANX2/p11-hetero-tetramer (ANX2T). We present e...
Main Authors: | Anilkumar Gopalakrishnapillai, E Anders Kolb, Priyanka Dhanan, Robert W Mason, Andrew Napper, Sonali P Barwe |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4605480?pdf=render |
Similar Items
-
Modeling Transient Abnormal Myelopoiesis Using Induced Pluripotent Stem Cells and CRISPR/Cas9 Technology
by: Sonali P. Barwe, et al.
Published: (2020-12-01) -
Understanding the Mechanisms by Which Epigenetic Modifiers Avert Therapy Resistance in Cancer
by: Anthony Quagliano, et al.
Published: (2020-06-01) -
CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia
by: Lennart Lenk, et al.
Published: (2021-01-01) -
Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xenograft samples
by: Sonali P. Barwe, et al.
Published: (2020-03-01) -
A Detailed Analysis of Parameters Supporting the Engraftment and Growth of Chronic Lymphocytic Leukemia Cells in Immune-Deficient Mice
by: Piers E. M. Patten, et al.
Published: (2021-03-01)