Microbiologically-Synthesized Nanoparticles and Their Role in Silencing the Biofilm Signaling Cascade

The emergence of bacterial resistance to antibiotics has led to the search for alternate antimicrobial treatment strategies. Engineered nanoparticles (NPs) for efficient penetration into a living system have become more common in the world of health and hygiene. The use of microbial enzymes/proteins...

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Main Authors: Dibyajit Lahiri, Moupriya Nag, Hassan I. Sheikh, Tanmay Sarkar, Hisham Atan Edinur, Siddhartha Pati, Rina Rani Ray
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Microbiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.636588/full
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spelling doaj-d16ce3b5fad64cd98f4f597a0fd88c4a2021-02-25T09:23:38ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-02-011210.3389/fmicb.2021.636588636588Microbiologically-Synthesized Nanoparticles and Their Role in Silencing the Biofilm Signaling CascadeDibyajit Lahiri0Moupriya Nag1Hassan I. Sheikh2Tanmay Sarkar3Tanmay Sarkar4Hisham Atan Edinur5Siddhartha Pati6Siddhartha Pati7Rina Rani Ray8Department of Biotechnology, University of Engineering & Management, Kolkata, IndiaDepartment of Biotechnology, University of Engineering & Management, Kolkata, IndiaFaculty of Fisheries and Food Science, Universiti Malaysia Terengganu, Kuala Nerus, MalaysiaDepartment of Food Technology and Bio-Chemical Engineering, Jadavpur University, Kolkata, IndiaMalda Polytechnic, West Bengal State Council of Technical Education, Govt. of West Bengal, Malda, IndiaSchool of Health Sciences, Universiti Sains Malaysia, Penang, MalaysiaCentre of Excellence, Khallikote University, Berhampur, Ganjam, Odisha, IndiaResearch Division, Association for Biodiversity Conservation and Research (ABC), Balasore, IndiaDepartment of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata, IndiaThe emergence of bacterial resistance to antibiotics has led to the search for alternate antimicrobial treatment strategies. Engineered nanoparticles (NPs) for efficient penetration into a living system have become more common in the world of health and hygiene. The use of microbial enzymes/proteins as a potential reducing agent for synthesizing NPs has increased rapidly in comparison to physical and chemical methods. It is a fast, environmentally safe, and cost-effective approach. Among the biogenic sources, fungi and bacteria are preferred not only for their ability to produce a higher titer of reductase enzyme to convert the ionic forms into their nano forms, but also for their convenience in cultivating and regulating the size and morphology of the synthesized NPs, which can effectively reduce the cost for large-scale manufacturing. Effective penetration through exopolysaccharides of a biofilm matrix enables the NPs to inhibit the bacterial growth. Biofilm is the consortia of sessile groups of microbial cells that are able to adhere to biotic and abiotic surfaces with the help extracellular polymeric substances and glycocalyx. These biofilms cause various chronic diseases and lead to biofouling on medical devices and implants. The NPs penetrate the biofilm and affect the quorum-sensing gene cascades and thereby hamper the cell-to-cell communication mechanism, which inhibits biofilm synthesis. This review focuses on the microbial nano-techniques that were used to produce various metallic and non-metallic nanoparticles and their “signal jamming effects” to inhibit biofilm formation. Detailed analysis and discussion is given to their interactions with various types of signal molecules and the genes responsible for the development of biofilm.https://www.frontiersin.org/articles/10.3389/fmicb.2021.636588/fullmicronanotechniquenanoparticlesantibiofilmquorum-sensingquorum quencher
collection DOAJ
language English
format Article
sources DOAJ
author Dibyajit Lahiri
Moupriya Nag
Hassan I. Sheikh
Tanmay Sarkar
Tanmay Sarkar
Hisham Atan Edinur
Siddhartha Pati
Siddhartha Pati
Rina Rani Ray
spellingShingle Dibyajit Lahiri
Moupriya Nag
Hassan I. Sheikh
Tanmay Sarkar
Tanmay Sarkar
Hisham Atan Edinur
Siddhartha Pati
Siddhartha Pati
Rina Rani Ray
Microbiologically-Synthesized Nanoparticles and Their Role in Silencing the Biofilm Signaling Cascade
Frontiers in Microbiology
micronanotechnique
nanoparticles
antibiofilm
quorum-sensing
quorum quencher
author_facet Dibyajit Lahiri
Moupriya Nag
Hassan I. Sheikh
Tanmay Sarkar
Tanmay Sarkar
Hisham Atan Edinur
Siddhartha Pati
Siddhartha Pati
Rina Rani Ray
author_sort Dibyajit Lahiri
title Microbiologically-Synthesized Nanoparticles and Their Role in Silencing the Biofilm Signaling Cascade
title_short Microbiologically-Synthesized Nanoparticles and Their Role in Silencing the Biofilm Signaling Cascade
title_full Microbiologically-Synthesized Nanoparticles and Their Role in Silencing the Biofilm Signaling Cascade
title_fullStr Microbiologically-Synthesized Nanoparticles and Their Role in Silencing the Biofilm Signaling Cascade
title_full_unstemmed Microbiologically-Synthesized Nanoparticles and Their Role in Silencing the Biofilm Signaling Cascade
title_sort microbiologically-synthesized nanoparticles and their role in silencing the biofilm signaling cascade
publisher Frontiers Media S.A.
series Frontiers in Microbiology
issn 1664-302X
publishDate 2021-02-01
description The emergence of bacterial resistance to antibiotics has led to the search for alternate antimicrobial treatment strategies. Engineered nanoparticles (NPs) for efficient penetration into a living system have become more common in the world of health and hygiene. The use of microbial enzymes/proteins as a potential reducing agent for synthesizing NPs has increased rapidly in comparison to physical and chemical methods. It is a fast, environmentally safe, and cost-effective approach. Among the biogenic sources, fungi and bacteria are preferred not only for their ability to produce a higher titer of reductase enzyme to convert the ionic forms into their nano forms, but also for their convenience in cultivating and regulating the size and morphology of the synthesized NPs, which can effectively reduce the cost for large-scale manufacturing. Effective penetration through exopolysaccharides of a biofilm matrix enables the NPs to inhibit the bacterial growth. Biofilm is the consortia of sessile groups of microbial cells that are able to adhere to biotic and abiotic surfaces with the help extracellular polymeric substances and glycocalyx. These biofilms cause various chronic diseases and lead to biofouling on medical devices and implants. The NPs penetrate the biofilm and affect the quorum-sensing gene cascades and thereby hamper the cell-to-cell communication mechanism, which inhibits biofilm synthesis. This review focuses on the microbial nano-techniques that were used to produce various metallic and non-metallic nanoparticles and their “signal jamming effects” to inhibit biofilm formation. Detailed analysis and discussion is given to their interactions with various types of signal molecules and the genes responsible for the development of biofilm.
topic micronanotechnique
nanoparticles
antibiofilm
quorum-sensing
quorum quencher
url https://www.frontiersin.org/articles/10.3389/fmicb.2021.636588/full
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