STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells

STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells

STIM proteins sense Ca2+ depletion in the ER and activate store-operated Ca2+-entry (SOCE) in response, a process associated with dendritic cell functions. Here the authors show STIM1 is the major isoform controlling SOCE in mouse dendritic cells and provide a mechanism for its requirement in antige...

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Main Authors: Paula Nunes-Hasler, Sophia Maschalidi, Carla Lippens, Cyril Castelbou, Samuel Bouvet, Daniele Guido, Flavien Bermont, Esen Y. Bassoy, Nicolas Page, Doron Merkler, Stéphanie Hugues, Denis Martinvalet, Bénédicte Manoury, Nicolas Demaurex
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01600-6
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spelling doaj-d16f804a8f3d4c7abd46394836e7b3e12021-05-11T07:12:28ZengNature Publishing GroupNature Communications2041-17232017-11-018111510.1038/s41467-017-01600-6STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cellsPaula Nunes-Hasler0Sophia Maschalidi1Carla Lippens2Cyril Castelbou3Samuel Bouvet4Daniele Guido5Flavien Bermont6Esen Y. Bassoy7Nicolas Page8Doron Merkler9Stéphanie Hugues10Denis Martinvalet11Bénédicte Manoury12Nicolas Demaurex13Department of Cell Physiology and Metabolism, University of GenevaLaboratory of Normal and Pathological Homeostasis of the Immune System, INSERM UMR1163Department of Pathology and Immunology, University of GenevaDepartment of Cell Physiology and Metabolism, University of GenevaDepartment of Cell Physiology and Metabolism, University of GenevaDepartment of Cell Physiology and Metabolism, University of GenevaDepartment of Cell Physiology and Metabolism, University of GenevaDepartment of Cell Physiology and Metabolism, University of GenevaDepartment of Pathology and Immunology, University of GenevaDepartment of Pathology and Immunology, University of GenevaDepartment of Pathology and Immunology, University of GenevaDepartment of Cell Physiology and Metabolism, University of GenevaUniversité Paris Descartes, Sorbonne Paris Cité, Faculté de médecine Paris DescartesDepartment of Cell Physiology and Metabolism, University of GenevaSTIM proteins sense Ca2+ depletion in the ER and activate store-operated Ca2+-entry (SOCE) in response, a process associated with dendritic cell functions. Here the authors show STIM1 is the major isoform controlling SOCE in mouse dendritic cells and provide a mechanism for its requirement in antigen cross-presentation.https://doi.org/10.1038/s41467-017-01600-6
collection DOAJ
language English
format Article
sources DOAJ
author Paula Nunes-Hasler
Sophia Maschalidi
Carla Lippens
Cyril Castelbou
Samuel Bouvet
Daniele Guido
Flavien Bermont
Esen Y. Bassoy
Nicolas Page
Doron Merkler
Stéphanie Hugues
Denis Martinvalet
Bénédicte Manoury
Nicolas Demaurex
spellingShingle Paula Nunes-Hasler
Sophia Maschalidi
Carla Lippens
Cyril Castelbou
Samuel Bouvet
Daniele Guido
Flavien Bermont
Esen Y. Bassoy
Nicolas Page
Doron Merkler
Stéphanie Hugues
Denis Martinvalet
Bénédicte Manoury
Nicolas Demaurex
STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells
Nature Communications
author_facet Paula Nunes-Hasler
Sophia Maschalidi
Carla Lippens
Cyril Castelbou
Samuel Bouvet
Daniele Guido
Flavien Bermont
Esen Y. Bassoy
Nicolas Page
Doron Merkler
Stéphanie Hugues
Denis Martinvalet
Bénédicte Manoury
Nicolas Demaurex
author_sort Paula Nunes-Hasler
title STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells
title_short STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells
title_full STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells
title_fullStr STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells
title_full_unstemmed STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells
title_sort stim1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description STIM proteins sense Ca2+ depletion in the ER and activate store-operated Ca2+-entry (SOCE) in response, a process associated with dendritic cell functions. Here the authors show STIM1 is the major isoform controlling SOCE in mouse dendritic cells and provide a mechanism for its requirement in antigen cross-presentation.
url https://doi.org/10.1038/s41467-017-01600-6
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