Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy
For an activating immunotherapy such as adjuvants, a compound that can prolong immune stimulation may enhance efficacy. We leveraged data from two prior high throughput screens with NF-κB and interferon reporter cell lines to identify 4H-chromene-3-carbonitriles as a class of compounds that prolonge...
Main Authors: | Fumi Sato-Kaneko, Xiaodong Wang, Shiyin Yao, Tadashi Hosoya, Fitzgerald S. Lao, Karen Messer, Minya Pu, Nikunj M. Shukla, Howard B. Cottam, Michael Chan, Dennis A. Carson, Maripat Corr, Tomoko Hayashi |
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Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2018-01-01
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Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2018/8091283 |
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