Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis
Objective To analyze the positivity of human leukocyte surface antigen-B27 (HLA-B27) in patients with suspected ankylosing spondylitis (AS) and their relatives in Chongqing to understand the gender-specific distribution of HLA-B27 genotypes in the patients. Methods We retrospectively analyzed the cl...
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doaj-d177d8f38fe2463f8f53702bcaf432cd2021-05-13T07:50:53ZzhoEditorial Office of Journal of Third Military Medical UniversityDi-san junyi daxue xuebao1000-54042020-06-0142121220122410.16016/j.1000-5404.202001204Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis GAO Lenyu0WU Hong1YOU Qingxia2WANG Yong3Department of Rheumatology and Immunology, First Affiliated Hospital, Army Medical University(Third Military Medical University), Chongqing, 400038, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital, Army Medical University(Third Military Medical University), Chongqing, 400038, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital, Army Medical University(Third Military Medical University), Chongqing, 400038, ChinaDepartment of Rheumatology and Immunology, First Affiliated Hospital, Army Medical University(Third Military Medical University), Chongqing, 400038, ChinaObjective To analyze the positivity of human leukocyte surface antigen-B27 (HLA-B27) in patients with suspected ankylosing spondylitis (AS) and their relatives in Chongqing to understand the gender-specific distribution of HLA-B27 genotypes in the patients. Methods We retrospectively analyzed the clinical data of 7 829 patients with suspected AS and some of their relatives, who were diagnosed in Chongqing between January 1, 2018 and November 29, 2019. HLA-B27 genotypes were determined using a sequence-specific primer polymerase chain reaction (PCR-SSP). Results Of the 7 829 patients, 2 112 were positive for HLA-B27 antigen, with a positive rate of 26. 98%. The positive rate of HLA-B27 antigen was significantly higher in the male than in the female patients (33.87% vs 18.58%, P < 0.01). A total of 1 655 (78. 36%) patients had a B* 2704 genotype and 358 (16.95%) had a B* 2705/07 genotype of HLA-B27 antigen. Forty-six of the HLA-B27-positive patients were found to have ocular diseases, among whom 36 (78.26%) patients had a B* 2704 genotype; uveitis was the most frequent ocular disease in these patients (34/46). Conclusion The patients with suspected AS in Chongqing have a significantly higher rate HLA- B27 antigen positivity than the normal population, and the positive rate is significantly higher in male than in female patients. The HLA-B27 genotypes are predominantly B * 2704 and B * 2705/07, and the former is associated with AS susceptibility. Uveitis is common in HLA-B27-positive AS patients with ocular diseases, who have a predominant B * 2704 genotype.http://aammt.tmmu.edu.cn/Upload/rhtml/202001204.htmhla-b27subtypeankylosing spondylitis |
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DOAJ |
language |
zho |
format |
Article |
sources |
DOAJ |
author |
GAO Lenyu WU Hong YOU Qingxia WANG Yong |
spellingShingle |
GAO Lenyu WU Hong YOU Qingxia WANG Yong Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis Di-san junyi daxue xuebao hla-b27 subtype ankylosing spondylitis |
author_facet |
GAO Lenyu WU Hong YOU Qingxia WANG Yong |
author_sort |
GAO Lenyu |
title |
Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis |
title_short |
Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis |
title_full |
Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis |
title_fullStr |
Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis |
title_full_unstemmed |
Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis |
title_sort |
positivity and genotype distribution of hla-b27 antigen in 7 829 patients with suspected ankylosing spondylitis |
publisher |
Editorial Office of Journal of Third Military Medical University |
series |
Di-san junyi daxue xuebao |
issn |
1000-5404 |
publishDate |
2020-06-01 |
description |
Objective To analyze the positivity of human leukocyte surface antigen-B27 (HLA-B27) in patients with suspected ankylosing spondylitis (AS) and their relatives in Chongqing to understand the gender-specific distribution of HLA-B27 genotypes in the patients. Methods We retrospectively analyzed the clinical data of 7 829 patients with suspected AS and some of their relatives, who were diagnosed in Chongqing between January 1, 2018 and November 29, 2019. HLA-B27 genotypes were determined using a sequence-specific primer polymerase chain reaction (PCR-SSP). Results Of the 7 829 patients, 2 112 were positive for HLA-B27 antigen, with a positive rate of 26. 98%. The positive rate of HLA-B27 antigen was significantly higher in the male than in the female patients (33.87% vs 18.58%, P < 0.01). A total of 1 655 (78. 36%) patients had a B* 2704 genotype and 358 (16.95%) had a B* 2705/07 genotype of HLA-B27 antigen. Forty-six of the HLA-B27-positive patients were found to have ocular diseases, among whom 36 (78.26%) patients had a B* 2704 genotype; uveitis was the most frequent ocular disease in these patients (34/46). Conclusion The patients with suspected AS in Chongqing have a significantly higher rate HLA- B27 antigen positivity than the normal population, and the positive rate is significantly higher in male than in female patients. The HLA-B27 genotypes are predominantly B * 2704 and B * 2705/07, and the former is associated with AS susceptibility. Uveitis is common in HLA-B27-positive AS patients with ocular diseases, who have a predominant B * 2704 genotype. |
topic |
hla-b27 subtype ankylosing spondylitis |
url |
http://aammt.tmmu.edu.cn/Upload/rhtml/202001204.htm |
work_keys_str_mv |
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