Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis
Abstract Lack of CD2-associated protein (CD2AP) in mice increases podocyte apoptosis and leads to glomerulosclerosis and renal failure. We showed previously that SHIP2, a negative regulator of the PI3K/AKT signalling pathway, interacts with CD2AP. Here, we found that the expression level and activit...
Main Authors: | Pauliina Saurus, Tuomas A. Tolvanen, Sonja Lindfors, Sara Kuusela, Harry Holthöfer, Eero Lehtonen, Sanna Lehtonen |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-09-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-10512-w |
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