Acute and Subchronic Toxicity Studies of Aqueous Extract of (Sw) DC
Extracts of Desmodium adscendens (Sw) DC are used for the treatment of various diseases but limited toxicological evaluations have been done on the medicinal plant. This study investigates toxicity effects of the leave extract of D adscendens , and the possibility of drug-drug interaction of the pla...
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Online Access: | https://doi.org/10.1177/2156587217736587 |
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doaj-d18daf5d1d3e458f9f363371e6525c192020-11-25T01:23:19ZengSAGE PublishingJournal of Evidence-Based Complementary & Alternative Medicine2156-58722156-58992017-10-012210.1177/2156587217736587Acute and Subchronic Toxicity Studies of Aqueous Extract of (Sw) DCOsbourne Quaye PhD0Precious Cramer MPhil1Mark Ofosuhene PhD2Laud K. N. Okine PhD3Alexander K. Nyarko PhD4 West African Center for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon, Accra, Ghana West African Center for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon, Accra, Ghana Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana West African Center for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon, Accra, Ghana School of Pharmacy, University of Ghana, Legon, Accra, GhanaExtracts of Desmodium adscendens (Sw) DC are used for the treatment of various diseases but limited toxicological evaluations have been done on the medicinal plant. This study investigates toxicity effects of the leave extract of D adscendens , and the possibility of drug-drug interaction of the plant extract when co-administered with other drugs. Oral administrations of leaf extract of D adscendens to white Wistar rats in an acute toxicity studies allowed the estimation of an LD 50 (median lethal dose) value of 1122 mg/kg body weight. In a subchronic toxicity studies, the plant extract caused a decrease in zoxazolamine paralysis time and prevented thiopentone from causing sleep in test animals compared to controls. Overall, the results are consistent with the plant extract being safe at the doses administered in humans. However, the induction of the CYP enzymes is an indication of a possible drug interaction when the plant extract is co-administered with other drugs.https://doi.org/10.1177/2156587217736587 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Osbourne Quaye PhD Precious Cramer MPhil Mark Ofosuhene PhD Laud K. N. Okine PhD Alexander K. Nyarko PhD |
spellingShingle |
Osbourne Quaye PhD Precious Cramer MPhil Mark Ofosuhene PhD Laud K. N. Okine PhD Alexander K. Nyarko PhD Acute and Subchronic Toxicity Studies of Aqueous Extract of (Sw) DC Journal of Evidence-Based Complementary & Alternative Medicine |
author_facet |
Osbourne Quaye PhD Precious Cramer MPhil Mark Ofosuhene PhD Laud K. N. Okine PhD Alexander K. Nyarko PhD |
author_sort |
Osbourne Quaye PhD |
title |
Acute and Subchronic Toxicity Studies of Aqueous Extract of (Sw) DC |
title_short |
Acute and Subchronic Toxicity Studies of Aqueous Extract of (Sw) DC |
title_full |
Acute and Subchronic Toxicity Studies of Aqueous Extract of (Sw) DC |
title_fullStr |
Acute and Subchronic Toxicity Studies of Aqueous Extract of (Sw) DC |
title_full_unstemmed |
Acute and Subchronic Toxicity Studies of Aqueous Extract of (Sw) DC |
title_sort |
acute and subchronic toxicity studies of aqueous extract of (sw) dc |
publisher |
SAGE Publishing |
series |
Journal of Evidence-Based Complementary & Alternative Medicine |
issn |
2156-5872 2156-5899 |
publishDate |
2017-10-01 |
description |
Extracts of Desmodium adscendens (Sw) DC are used for the treatment of various diseases but limited toxicological evaluations have been done on the medicinal plant. This study investigates toxicity effects of the leave extract of D adscendens , and the possibility of drug-drug interaction of the plant extract when co-administered with other drugs. Oral administrations of leaf extract of D adscendens to white Wistar rats in an acute toxicity studies allowed the estimation of an LD 50 (median lethal dose) value of 1122 mg/kg body weight. In a subchronic toxicity studies, the plant extract caused a decrease in zoxazolamine paralysis time and prevented thiopentone from causing sleep in test animals compared to controls. Overall, the results are consistent with the plant extract being safe at the doses administered in humans. However, the induction of the CYP enzymes is an indication of a possible drug interaction when the plant extract is co-administered with other drugs. |
url |
https://doi.org/10.1177/2156587217736587 |
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