Reduced cortical thickness in World Trade Center responders with cognitive impairment
Abstract Introduction This study examined cortical thickness (CTX) in World Trade Center (WTC) responders with cognitive impairment (CI). Methods WTC responders (N = 99) with/without CI, recruited from an epidemiologic study, completed a T1‐MPRAGE protocol. CTX was automatically computed in 34 regio...
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doaj-d1903688916e4183a730c1348cc8f7d42021-04-15T14:35:48ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292020-01-01121n/an/a10.1002/dad2.12059Reduced cortical thickness in World Trade Center responders with cognitive impairmentSean A. P. Clouston0Yael Deri1Megan Horton2Cheuk Tang3Erica Diminich4Christine DeLorenzo5Minos Kritikos6Alison C. Pellecchia7Stephanie Santiago‐Michels8Melissa A. Carr9Samuel Gandy10Mary Sano11Evelyn J. Bromet12Roberto G. Lucchini13Benjamin J. Luft14Program in Public Health Department of Family, Population, and Preventive Medicine Renaissance School of Medicine at Stony Brook University Stony Brook New York USADepartment of Medicine Renaissance School of Medicine at Stony Brook University Stony Brook New York USADepartment of Environmental Medicine and Public Health Icahn School of Medicine at Mount Sinai New York New York USADepartment of Radiology Icahn School of Medicine at Mount Sinai New York New York USAProgram in Public Health Department of Family, Population, and Preventive Medicine Renaissance School of Medicine at Stony Brook University Stony Brook New York USADepartment of Psychiatry Renaissance School of Medicine at Stony Brook University Stony Brook New York USAProgram in Public Health Department of Family, Population, and Preventive Medicine Renaissance School of Medicine at Stony Brook University Stony Brook New York USAStony Brook World Trade Center Wellness Program Renaissance School of Medicine at Stony Brook University Stony Brook New York USAStony Brook World Trade Center Wellness Program Renaissance School of Medicine at Stony Brook University Stony Brook New York USAStony Brook World Trade Center Wellness Program Renaissance School of Medicine at Stony Brook University Stony Brook New York USADepartment of Neurology Icahn School of Medicine at Mount Sinai New York New York USADepartment of Psychiatry and Mount Sinai Alzheimer's Disease Research Center Icahn School of Medicine at Mount Sinai New York New York USADepartment of Psychiatry Renaissance School of Medicine at Stony Brook University Stony Brook New York USADepartment of Environmental Medicine and Public Health Icahn School of Medicine at Mount Sinai New York New York USADepartment of Medicine Renaissance School of Medicine at Stony Brook University Stony Brook New York USAAbstract Introduction This study examined cortical thickness (CTX) in World Trade Center (WTC) responders with cognitive impairment (CI). Methods WTC responders (N = 99) with/without CI, recruited from an epidemiologic study, completed a T1‐MPRAGE protocol. CTX was automatically computed in 34 regions of interest. Region‐based and surface‐based morphometry examined CTX in CI versus unimpaired responders. CTX was automatically computed in 34 regions of interest. Region‐based measures were also compared to published norms. Results Participants were 55.8 (SD = 0.52) years old; 48 had CI. Compared to unimpaired responders, global mean CTX was reduced in CI and across 21/34 cortical subregions. Surface‐based analyses revealed reduced CTX across frontal, temporal, and parietal lobes when adjusting for multiple comparisons. Both CI and unimpaired WTC groups had reduced CTX in the entorhinal and temporal cortices compared to published normative data. Discussion Results from the first structural magnetic resonance imaging study in WTC responders identified reduced CTX consistent with a neurodegenerative disease of unknown etiology.https://doi.org/10.1002/dad2.12059cognitive impairmentcortical thicknessWorld Trade Center responders |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sean A. P. Clouston Yael Deri Megan Horton Cheuk Tang Erica Diminich Christine DeLorenzo Minos Kritikos Alison C. Pellecchia Stephanie Santiago‐Michels Melissa A. Carr Samuel Gandy Mary Sano Evelyn J. Bromet Roberto G. Lucchini Benjamin J. Luft |
spellingShingle |
Sean A. P. Clouston Yael Deri Megan Horton Cheuk Tang Erica Diminich Christine DeLorenzo Minos Kritikos Alison C. Pellecchia Stephanie Santiago‐Michels Melissa A. Carr Samuel Gandy Mary Sano Evelyn J. Bromet Roberto G. Lucchini Benjamin J. Luft Reduced cortical thickness in World Trade Center responders with cognitive impairment Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring cognitive impairment cortical thickness World Trade Center responders |
author_facet |
Sean A. P. Clouston Yael Deri Megan Horton Cheuk Tang Erica Diminich Christine DeLorenzo Minos Kritikos Alison C. Pellecchia Stephanie Santiago‐Michels Melissa A. Carr Samuel Gandy Mary Sano Evelyn J. Bromet Roberto G. Lucchini Benjamin J. Luft |
author_sort |
Sean A. P. Clouston |
title |
Reduced cortical thickness in World Trade Center responders with cognitive impairment |
title_short |
Reduced cortical thickness in World Trade Center responders with cognitive impairment |
title_full |
Reduced cortical thickness in World Trade Center responders with cognitive impairment |
title_fullStr |
Reduced cortical thickness in World Trade Center responders with cognitive impairment |
title_full_unstemmed |
Reduced cortical thickness in World Trade Center responders with cognitive impairment |
title_sort |
reduced cortical thickness in world trade center responders with cognitive impairment |
publisher |
Wiley |
series |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
issn |
2352-8729 |
publishDate |
2020-01-01 |
description |
Abstract Introduction This study examined cortical thickness (CTX) in World Trade Center (WTC) responders with cognitive impairment (CI). Methods WTC responders (N = 99) with/without CI, recruited from an epidemiologic study, completed a T1‐MPRAGE protocol. CTX was automatically computed in 34 regions of interest. Region‐based and surface‐based morphometry examined CTX in CI versus unimpaired responders. CTX was automatically computed in 34 regions of interest. Region‐based measures were also compared to published norms. Results Participants were 55.8 (SD = 0.52) years old; 48 had CI. Compared to unimpaired responders, global mean CTX was reduced in CI and across 21/34 cortical subregions. Surface‐based analyses revealed reduced CTX across frontal, temporal, and parietal lobes when adjusting for multiple comparisons. Both CI and unimpaired WTC groups had reduced CTX in the entorhinal and temporal cortices compared to published normative data. Discussion Results from the first structural magnetic resonance imaging study in WTC responders identified reduced CTX consistent with a neurodegenerative disease of unknown etiology. |
topic |
cognitive impairment cortical thickness World Trade Center responders |
url |
https://doi.org/10.1002/dad2.12059 |
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