Emotion Regulation of Hippocampus Using Real-Time fMRI Neurofeedback in Healthy Human
Real-time functional magnetic resonance imaging neurofeedback (rtfMRI-NF) is a prospective tool to enhance the emotion regulation capability of participants and to alleviate their emotional disorders. The hippocampus is a key brain region in the emotional brain network and plays a significant role i...
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doaj-d19171f6dfb34ff292702a6276625fa72020-11-25T02:19:05ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612019-07-011310.3389/fnhum.2019.00242444712Emotion Regulation of Hippocampus Using Real-Time fMRI Neurofeedback in Healthy HumanYashuo Zhu0Hui Gao1Li Tong2ZhongLin Li3Linyuan Wang4Chi Zhang5Qiang Yang6Bin Yan7PLA Strategy Support Force Information Engineering University, Communication Engineering College, Zhengzhou, ChinaPLA Strategy Support Force Information Engineering University, Communication Engineering College, Zhengzhou, ChinaPLA Strategy Support Force Information Engineering University, Communication Engineering College, Zhengzhou, ChinaDepartment of Radiology, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Zhengzhou, ChinaPLA Strategy Support Force Information Engineering University, Communication Engineering College, Zhengzhou, ChinaPLA Strategy Support Force Information Engineering University, Communication Engineering College, Zhengzhou, ChinaPLA Strategy Support Force Information Engineering University, Communication Engineering College, Zhengzhou, ChinaPLA Strategy Support Force Information Engineering University, Communication Engineering College, Zhengzhou, ChinaReal-time functional magnetic resonance imaging neurofeedback (rtfMRI-NF) is a prospective tool to enhance the emotion regulation capability of participants and to alleviate their emotional disorders. The hippocampus is a key brain region in the emotional brain network and plays a significant role in social cognition and emotion processing in the brain. However, few studies have focused on the emotion NF of the hippocampus. This study investigated the feasibility of NF training of healthy participants to self-regulate the activation of the hippocampus and assessed the effect of rtfMRI-NF on the hippocampus before and after training. Twenty-six right-handed healthy volunteers were randomly assigned to the experimental group receiving hippocampal rtfMRI-NF (n = 13) and the control group (CG) receiving rtfMRI-NF from the intraparietal sulcus rtfMRI-NF (n = 13) and completed a total of four NF runs. The hippocampus and the intraparietal sulcus were defined based on the Montreal Neurological Institute (MNI) standard template, and NF signal was measured as a percent signal change relative to the baseline obtained by averaging the fMRI signal for the preceding 20 s long rest block. NF signal (percent signal change) was updated every 2 s and was displayed on the screen. The amplitude of low-frequency fluctuation and regional homogeneity values was calculated to evaluate the effects of NF on spontaneous neural activity in resting-state fMRI. A standard general linear model (GLM) analysis was separately conducted for each fMRI NF run. Results showed that the activation of hippocampus increased after four NF training runs. The hippocampal activity of the experiment group participants was higher than that of the CG. They also showed elevated hippocampal activity and the greater amygdala–hippocampus connectivity. The anterior temporal lobe, parahippocampal gyrus, hippocampus, and amygdala of brain regions associated with emotional processing were activated during training. We presented a proof-of-concept study using rtfMRI-NF for hippocampus up-regulation in the recall of positive autobiographical memories. The current study may provide a new method to regulate our emotions and can potentially be applied to the clinical treatment of emotional disorders.https://www.frontiersin.org/article/10.3389/fnhum.2019.00242/fullhippocampusreal-time fMRI neurofeedbackemotionregulationautobiographical memories |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yashuo Zhu Hui Gao Li Tong ZhongLin Li Linyuan Wang Chi Zhang Qiang Yang Bin Yan |
spellingShingle |
Yashuo Zhu Hui Gao Li Tong ZhongLin Li Linyuan Wang Chi Zhang Qiang Yang Bin Yan Emotion Regulation of Hippocampus Using Real-Time fMRI Neurofeedback in Healthy Human Frontiers in Human Neuroscience hippocampus real-time fMRI neurofeedback emotion regulation autobiographical memories |
author_facet |
Yashuo Zhu Hui Gao Li Tong ZhongLin Li Linyuan Wang Chi Zhang Qiang Yang Bin Yan |
author_sort |
Yashuo Zhu |
title |
Emotion Regulation of Hippocampus Using Real-Time fMRI Neurofeedback in Healthy Human |
title_short |
Emotion Regulation of Hippocampus Using Real-Time fMRI Neurofeedback in Healthy Human |
title_full |
Emotion Regulation of Hippocampus Using Real-Time fMRI Neurofeedback in Healthy Human |
title_fullStr |
Emotion Regulation of Hippocampus Using Real-Time fMRI Neurofeedback in Healthy Human |
title_full_unstemmed |
Emotion Regulation of Hippocampus Using Real-Time fMRI Neurofeedback in Healthy Human |
title_sort |
emotion regulation of hippocampus using real-time fmri neurofeedback in healthy human |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2019-07-01 |
description |
Real-time functional magnetic resonance imaging neurofeedback (rtfMRI-NF) is a prospective tool to enhance the emotion regulation capability of participants and to alleviate their emotional disorders. The hippocampus is a key brain region in the emotional brain network and plays a significant role in social cognition and emotion processing in the brain. However, few studies have focused on the emotion NF of the hippocampus. This study investigated the feasibility of NF training of healthy participants to self-regulate the activation of the hippocampus and assessed the effect of rtfMRI-NF on the hippocampus before and after training. Twenty-six right-handed healthy volunteers were randomly assigned to the experimental group receiving hippocampal rtfMRI-NF (n = 13) and the control group (CG) receiving rtfMRI-NF from the intraparietal sulcus rtfMRI-NF (n = 13) and completed a total of four NF runs. The hippocampus and the intraparietal sulcus were defined based on the Montreal Neurological Institute (MNI) standard template, and NF signal was measured as a percent signal change relative to the baseline obtained by averaging the fMRI signal for the preceding 20 s long rest block. NF signal (percent signal change) was updated every 2 s and was displayed on the screen. The amplitude of low-frequency fluctuation and regional homogeneity values was calculated to evaluate the effects of NF on spontaneous neural activity in resting-state fMRI. A standard general linear model (GLM) analysis was separately conducted for each fMRI NF run. Results showed that the activation of hippocampus increased after four NF training runs. The hippocampal activity of the experiment group participants was higher than that of the CG. They also showed elevated hippocampal activity and the greater amygdala–hippocampus connectivity. The anterior temporal lobe, parahippocampal gyrus, hippocampus, and amygdala of brain regions associated with emotional processing were activated during training. We presented a proof-of-concept study using rtfMRI-NF for hippocampus up-regulation in the recall of positive autobiographical memories. The current study may provide a new method to regulate our emotions and can potentially be applied to the clinical treatment of emotional disorders. |
topic |
hippocampus real-time fMRI neurofeedback emotion regulation autobiographical memories |
url |
https://www.frontiersin.org/article/10.3389/fnhum.2019.00242/full |
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