From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization

From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization

Alloimmunization is an undesirable iatrogenic effect of transfusion and transplantation. In fact, recipients can be considered as responders or not responders, in a continuum from tolerance, including organ transplantation and transfusion, to polyimmunized and refractory patients. New models and lar...

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Main Authors: Antoine Prigent, Nicolas Maillard, Léna Absi, Chaker Aloui, Fabrice Cognasse, Sandrine Laradi, Christophe Mariat, Olivier Garraud
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:Antibodies
Subjects:
transfusion
transplantation
alloimmunization
tolerance
HLA
Online Access:http://www.mdpi.com/2073-4468/3/1/130
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spelling doaj-d19ab0dd67ad43748d3c3635d2d832122020-11-24T23:52:20ZengMDPI AGAntibodies2073-44682014-02-013113015210.3390/antib3010130antib3010130From Donor to Recipient: Current Questions Relating to Humoral AlloimmunizationAntoine Prigent0Nicolas Maillard1Léna Absi2Chaker Aloui3Fabrice Cognasse4Sandrine Laradi5Christophe Mariat6Olivier Garraud7GIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, FranceGIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, FranceEFS Auvergne-Loire, 42023 Saint-Etienne, FranceGIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, FranceGIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, FranceGIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, FranceGIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, FranceGIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, FranceAlloimmunization is an undesirable iatrogenic effect of transfusion and transplantation. In fact, recipients can be considered as responders or not responders, in a continuum from tolerance, including organ transplantation and transfusion, to polyimmunized and refractory patients. New models and large studies have enabled a better understanding of the mechanisms that induce specific alloantibody (alloAb) generation. Here, we focus on risk factors of alloimmunization. We review the alloantibody characteristics, summarize the different leukocytes involved in their induction, and suggest some hypotheses.http://www.mdpi.com/2073-4468/3/1/130transfusiontransplantationalloimmunizationtoleranceHLA
collection DOAJ
language English
format Article
sources DOAJ
author Antoine Prigent
Nicolas Maillard
Léna Absi
Chaker Aloui
Fabrice Cognasse
Sandrine Laradi
Christophe Mariat
Olivier Garraud
spellingShingle Antoine Prigent
Nicolas Maillard
Léna Absi
Chaker Aloui
Fabrice Cognasse
Sandrine Laradi
Christophe Mariat
Olivier Garraud
From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization
Antibodies
transfusion
transplantation
alloimmunization
tolerance
HLA
author_facet Antoine Prigent
Nicolas Maillard
Léna Absi
Chaker Aloui
Fabrice Cognasse
Sandrine Laradi
Christophe Mariat
Olivier Garraud
author_sort Antoine Prigent
title From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization
title_short From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization
title_full From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization
title_fullStr From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization
title_full_unstemmed From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization
title_sort from donor to recipient: current questions relating to humoral alloimmunization
publisher MDPI AG
series Antibodies
issn 2073-4468
publishDate 2014-02-01
description Alloimmunization is an undesirable iatrogenic effect of transfusion and transplantation. In fact, recipients can be considered as responders or not responders, in a continuum from tolerance, including organ transplantation and transfusion, to polyimmunized and refractory patients. New models and large studies have enabled a better understanding of the mechanisms that induce specific alloantibody (alloAb) generation. Here, we focus on risk factors of alloimmunization. We review the alloantibody characteristics, summarize the different leukocytes involved in their induction, and suggest some hypotheses.
topic transfusion
transplantation
alloimmunization
tolerance
HLA
url http://www.mdpi.com/2073-4468/3/1/130
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