Folic Acid and PEI Modified Mesoporous Silica for Targeted Delivery of Curcumin
Nano anti-cancer drug carriers loaded with antineoplastic drugs can achieve targeted drug delivery, which enriches drugs at tumor sites and reduces the toxic side effects in normal tissues. Mesoporous silica nanoparticles (MSN) are good nano drug carriers, as they have large specific surface areas,...
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doaj-d19c38e8b3b041138797405f7bb14ff72020-11-25T02:23:45ZengMDPI AGPharmaceutics1999-49232019-08-0111943010.3390/pharmaceutics11090430pharmaceutics11090430Folic Acid and PEI Modified Mesoporous Silica for Targeted Delivery of CurcuminXiaoxiao Sun0Nan Wang1Li-Ye Yang2Xiao-Kun Ouyang3Fangfang Huang4School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, ChinaSchool of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, ChinaSchool of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, ChinaSchool of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, ChinaSchool of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, ChinaNano anti-cancer drug carriers loaded with antineoplastic drugs can achieve targeted drug delivery, which enriches drugs at tumor sites and reduces the toxic side effects in normal tissues. Mesoporous silica nanoparticles (MSN) are good nano drug carriers, as they have large specific surface areas, adjustable pore sizes, easily modifiable surfaces, and good biocompatibility. In this work, polyethyleneimine (PEI) grafted MSN were modified with folic acid (FA) as an active target molecule using chemical methods. The product was characterized by SEM, TEM, Zetasizer nano, FTIR, and an N<sub>2</sub> adsorption and desorption test. MSN-PEI-FA are porous nano particles with an average particle size of approximately 100 nm. In addition, the loading rate and release behavior of MSN-PEI-FA were studied with curcumin as a model drug. The results show that when loading curcumin to MSN-PEI-FA at 7 mg and 0.1 g, respectively, the encapsulation efficiency was 90% and the cumulative release rate reached more than 50% within 120 h at pH = 5. This drug delivery system is suitable for loading fat-soluble antineoplastic drugs for sustained release and pH sensitive delivery.https://www.mdpi.com/1999-4923/11/9/430curcuminmesoporous silica nanoparticlesfunctionaldeliverycancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaoxiao Sun Nan Wang Li-Ye Yang Xiao-Kun Ouyang Fangfang Huang |
spellingShingle |
Xiaoxiao Sun Nan Wang Li-Ye Yang Xiao-Kun Ouyang Fangfang Huang Folic Acid and PEI Modified Mesoporous Silica for Targeted Delivery of Curcumin Pharmaceutics curcumin mesoporous silica nanoparticles functional delivery cancer |
author_facet |
Xiaoxiao Sun Nan Wang Li-Ye Yang Xiao-Kun Ouyang Fangfang Huang |
author_sort |
Xiaoxiao Sun |
title |
Folic Acid and PEI Modified Mesoporous Silica for Targeted Delivery of Curcumin |
title_short |
Folic Acid and PEI Modified Mesoporous Silica for Targeted Delivery of Curcumin |
title_full |
Folic Acid and PEI Modified Mesoporous Silica for Targeted Delivery of Curcumin |
title_fullStr |
Folic Acid and PEI Modified Mesoporous Silica for Targeted Delivery of Curcumin |
title_full_unstemmed |
Folic Acid and PEI Modified Mesoporous Silica for Targeted Delivery of Curcumin |
title_sort |
folic acid and pei modified mesoporous silica for targeted delivery of curcumin |
publisher |
MDPI AG |
series |
Pharmaceutics |
issn |
1999-4923 |
publishDate |
2019-08-01 |
description |
Nano anti-cancer drug carriers loaded with antineoplastic drugs can achieve targeted drug delivery, which enriches drugs at tumor sites and reduces the toxic side effects in normal tissues. Mesoporous silica nanoparticles (MSN) are good nano drug carriers, as they have large specific surface areas, adjustable pore sizes, easily modifiable surfaces, and good biocompatibility. In this work, polyethyleneimine (PEI) grafted MSN were modified with folic acid (FA) as an active target molecule using chemical methods. The product was characterized by SEM, TEM, Zetasizer nano, FTIR, and an N<sub>2</sub> adsorption and desorption test. MSN-PEI-FA are porous nano particles with an average particle size of approximately 100 nm. In addition, the loading rate and release behavior of MSN-PEI-FA were studied with curcumin as a model drug. The results show that when loading curcumin to MSN-PEI-FA at 7 mg and 0.1 g, respectively, the encapsulation efficiency was 90% and the cumulative release rate reached more than 50% within 120 h at pH = 5. This drug delivery system is suitable for loading fat-soluble antineoplastic drugs for sustained release and pH sensitive delivery. |
topic |
curcumin mesoporous silica nanoparticles functional delivery cancer |
url |
https://www.mdpi.com/1999-4923/11/9/430 |
work_keys_str_mv |
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