Tomographic Ultrasound and LED-Based Photoacoustic System for Preclinical Imaging

Small animals are widely used as disease models in medical research. Noninvasive imaging modalities with functional capability play an important role in studying the disease state and treatment progress. Photoacoustics, being a noninvasive and functional modality, has the potential for small-animal...

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Bibliographic Details
Main Authors: Kalloor Joseph Francis, Richell Booijink, Ruchi Bansal, Wiendelt Steenbergen
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Sensors
Subjects:
Online Access:https://www.mdpi.com/1424-8220/20/10/2793
Description
Summary:Small animals are widely used as disease models in medical research. Noninvasive imaging modalities with functional capability play an important role in studying the disease state and treatment progress. Photoacoustics, being a noninvasive and functional modality, has the potential for small-animal imaging. However, the conventional photoacoustic tomographic systems use pulsed lasers, making it expensive, bulky, and require long acquisition time. In this work, we propose the use of photoacoustic and ultrasound tomographic imaging with LEDs as the light source and acoustic detection using a linear transducer array. We have demonstrated full-view tomographic imaging of a euthanized mouse and a potential application in liver fibrosis research.
ISSN:1424-8220