Inclusion body myositis – pathomechanism and lessons from genetics
Inclusion body myositis is a rare, late-onset myopathy. Both inflammatory and myodegenerative features play an important role in their pathogenesis. Overlapping clinicopathological entities are the familial inclusion body myopathies with or without dementia. These myopathies share several clinical a...
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De Gruyter
2015-02-01
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| Series: | Open Medicine |
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doaj-d1ae49101b9542e5ba63cdf5445fa99c2021-10-02T03:10:13ZengDe GruyterOpen Medicine2391-54632015-02-0110110.1515/med-2015-0030med-2015-0030Inclusion body myositis – pathomechanism and lessons from geneticsMurnyák Balázs0Bodoki Levente1Vincze Melinda2Griger Zoltán3Csonka Tamás4Szepesi Rita5Kurucz Andrea6Dankó Katalin7Hortobágyi Tibor8Division of Neuropathology, Institute of PathologyInstitute of Internal Medicine, Third Department of Internal Medicine, Division of Clinical ImmunologyInstitute of Internal Medicine, Third Department of Internal Medicine, Division of Clinical ImmunologyInstitute of Internal Medicine, Third Department of Internal Medicine, Division of Clinical ImmunologyDivision of Neuropathology, Institute of PathologyDepartment of Neurology, University of Debrecen, Faculty of Medicine, Debrecen, HungaryDivision of Neuropathology, Institute of PathologyInstitute of Internal Medicine, Third Department of Internal Medicine, Division of Clinical ImmunologyUniversity of Debrecen, Faculty of Medicine, Institute of Pathology, Division of Neuropathology, 4032 Debrecen, Nagyerdei krt. 98. Tel.: + 36 52 255-248; e-mail: tibor.hortobagyi@kcl.ac.ukInclusion body myositis is a rare, late-onset myopathy. Both inflammatory and myodegenerative features play an important role in their pathogenesis. Overlapping clinicopathological entities are the familial inclusion body myopathies with or without dementia. These myopathies share several clinical and pathological features with the sporadic inflammatory disease. Therefore, better understanding of the genetic basis and pathomechanism of these rare familial cases may advance our knowledge and enable more effective treatment options in sporadic IBM, which is currently considered a relentlessly progressive incurable disease.http://www.degruyter.com/view/j/med.2015.10.issue-1/med-2015-0030/med-2015-0030.xml?format=INTsporadic inclusion body myositis genetics GNE DES VCPIBMPFD TDP-43 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Murnyák Balázs Bodoki Levente Vincze Melinda Griger Zoltán Csonka Tamás Szepesi Rita Kurucz Andrea Dankó Katalin Hortobágyi Tibor |
| spellingShingle |
Murnyák Balázs Bodoki Levente Vincze Melinda Griger Zoltán Csonka Tamás Szepesi Rita Kurucz Andrea Dankó Katalin Hortobágyi Tibor Inclusion body myositis – pathomechanism and lessons from genetics Open Medicine sporadic inclusion body myositis genetics GNE DES VCP IBMPFD TDP-43 |
| author_facet |
Murnyák Balázs Bodoki Levente Vincze Melinda Griger Zoltán Csonka Tamás Szepesi Rita Kurucz Andrea Dankó Katalin Hortobágyi Tibor |
| author_sort |
Murnyák Balázs |
| title |
Inclusion body myositis – pathomechanism and lessons from genetics |
| title_short |
Inclusion body myositis – pathomechanism and lessons from genetics |
| title_full |
Inclusion body myositis – pathomechanism and lessons from genetics |
| title_fullStr |
Inclusion body myositis – pathomechanism and lessons from genetics |
| title_full_unstemmed |
Inclusion body myositis – pathomechanism and lessons from genetics |
| title_sort |
inclusion body myositis – pathomechanism and lessons from genetics |
| publisher |
De Gruyter |
| series |
Open Medicine |
| issn |
2391-5463 |
| publishDate |
2015-02-01 |
| description |
Inclusion body myositis is a rare, late-onset
myopathy. Both inflammatory and myodegenerative
features play an important role in their pathogenesis.
Overlapping clinicopathological entities are the familial
inclusion body myopathies with or without dementia.
These myopathies share several clinical and pathological
features with the sporadic inflammatory disease.
Therefore, better understanding of the genetic basis and
pathomechanism of these rare familial cases may advance
our knowledge and enable more effective treatment
options in sporadic IBM, which is currently considered a
relentlessly progressive incurable disease. |
| topic |
sporadic inclusion body myositis genetics GNE DES VCP IBMPFD TDP-43 |
| url |
http://www.degruyter.com/view/j/med.2015.10.issue-1/med-2015-0030/med-2015-0030.xml?format=INT |
| work_keys_str_mv |
AT murnyakbalazs inclusionbodymyositispathomechanismandlessonsfromgenetics AT bodokilevente inclusionbodymyositispathomechanismandlessonsfromgenetics AT vinczemelinda inclusionbodymyositispathomechanismandlessonsfromgenetics AT grigerzoltan inclusionbodymyositispathomechanismandlessonsfromgenetics AT csonkatamas inclusionbodymyositispathomechanismandlessonsfromgenetics AT szepesirita inclusionbodymyositispathomechanismandlessonsfromgenetics AT kuruczandrea inclusionbodymyositispathomechanismandlessonsfromgenetics AT dankokatalin inclusionbodymyositispathomechanismandlessonsfromgenetics AT hortobagyitibor inclusionbodymyositispathomechanismandlessonsfromgenetics |
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1716860178676056064 |