Migrating Polyarthritis as a Feature of Occult Malignancy: 2 Case Reports and a Review of the Literature
Malignant disease may be associated with a wide variety of musculoskeletal syndromes. Rarely the musculoskeletal system can be indirectly affected by paraneoplastic phenomena, such as carcinomatous polyarthritis (CP). The differential diagnosis for CP is broad and is often a diagnosis of exclusion....
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Series: | Case Reports in Oncological Medicine |
Online Access: | http://dx.doi.org/10.1155/2015/934039 |
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doaj-d1b007821ac44a9186137641daac2ebf2020-11-24T23:01:19ZengHindawi LimitedCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/934039934039Migrating Polyarthritis as a Feature of Occult Malignancy: 2 Case Reports and a Review of the LiteratureGeoffrey Alan Watson0Lorraine O’Neill1Ruth Law2Geraldine McCarthy3Douglas Veale4St. Vincent’s University Hospital, Dublin, IrelandSt. Vincent’s University Hospital, Dublin, IrelandSt. Vincent’s University Hospital, Dublin, IrelandMater Misericordiae University Hospital, Dublin, IrelandSt. Vincent’s University Hospital, Dublin, IrelandMalignant disease may be associated with a wide variety of musculoskeletal syndromes. Rarely the musculoskeletal system can be indirectly affected by paraneoplastic phenomena, such as carcinomatous polyarthritis (CP). The differential diagnosis for CP is broad and is often a diagnosis of exclusion. CP often presents similarly to other forms of inflammatory arthritis, and a detailed history and physical examination can often distinguish CP from other more common causes of polyarticular arthritis. However serological tests such as rheumatoid factor (RF) and anti-citrullinated peptide (anti-CCP) antibody positivity, while rare, can be misleading. Clinical awareness and suspicion are paramount in achieving an accurate diagnosis and early detection of an occult neoplasm is critical for prompt management and therapy. We report two cases presenting with this unique clinical phenotype associated with paraneoplastic polyarthropathy and review the literature.http://dx.doi.org/10.1155/2015/934039 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Geoffrey Alan Watson Lorraine O’Neill Ruth Law Geraldine McCarthy Douglas Veale |
spellingShingle |
Geoffrey Alan Watson Lorraine O’Neill Ruth Law Geraldine McCarthy Douglas Veale Migrating Polyarthritis as a Feature of Occult Malignancy: 2 Case Reports and a Review of the Literature Case Reports in Oncological Medicine |
author_facet |
Geoffrey Alan Watson Lorraine O’Neill Ruth Law Geraldine McCarthy Douglas Veale |
author_sort |
Geoffrey Alan Watson |
title |
Migrating Polyarthritis as a Feature of Occult Malignancy: 2 Case Reports and a Review of the Literature |
title_short |
Migrating Polyarthritis as a Feature of Occult Malignancy: 2 Case Reports and a Review of the Literature |
title_full |
Migrating Polyarthritis as a Feature of Occult Malignancy: 2 Case Reports and a Review of the Literature |
title_fullStr |
Migrating Polyarthritis as a Feature of Occult Malignancy: 2 Case Reports and a Review of the Literature |
title_full_unstemmed |
Migrating Polyarthritis as a Feature of Occult Malignancy: 2 Case Reports and a Review of the Literature |
title_sort |
migrating polyarthritis as a feature of occult malignancy: 2 case reports and a review of the literature |
publisher |
Hindawi Limited |
series |
Case Reports in Oncological Medicine |
issn |
2090-6706 2090-6714 |
publishDate |
2015-01-01 |
description |
Malignant disease may be associated with a wide variety of musculoskeletal syndromes. Rarely the musculoskeletal system can be indirectly affected by paraneoplastic phenomena, such as carcinomatous polyarthritis (CP). The differential diagnosis for CP is broad and is often a diagnosis of exclusion. CP often presents similarly to other forms of inflammatory arthritis, and a detailed history and physical examination can often distinguish CP from other more common causes of polyarticular arthritis. However serological tests such as rheumatoid factor (RF) and anti-citrullinated peptide (anti-CCP) antibody positivity, while rare, can be misleading. Clinical awareness and suspicion are paramount in achieving an accurate diagnosis and early detection of an occult neoplasm is critical for prompt management and therapy. We report two cases presenting with this unique clinical phenotype associated with paraneoplastic polyarthropathy and review the literature. |
url |
http://dx.doi.org/10.1155/2015/934039 |
work_keys_str_mv |
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