Fecal calprotectin in inflammatory bowel disease
Natalie E Walsham,1 Roy A Sherwood2 1Department of Clinical Biochemistry, University Hospital Lewisham, Lewisham, 2Department of Clinical Biochemistry, Viapath at King’s College Hospital NHS Foundation Trust, London, UK Abstract: Inflammatory bowel disease (IBD) and irritable bowel syndro...
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doaj-d1b9893309ce4dd795325205cef408d32020-11-25T00:55:58ZengDove Medical PressClinical and Experimental Gastroenterology1178-70232016-01-012016Issue 1212925419Fecal calprotectin in inflammatory bowel diseaseWalsham NESherwood RANatalie E Walsham,1 Roy A Sherwood2 1Department of Clinical Biochemistry, University Hospital Lewisham, Lewisham, 2Department of Clinical Biochemistry, Viapath at King’s College Hospital NHS Foundation Trust, London, UK Abstract: Inflammatory bowel disease (IBD) and irritable bowel syndrome share many symptoms. While irritable bowel syndrome is a functional bowel disorder for which no specific treatment is available, the range of effective therapies for IBD is evolving rapidly. Accurate diagnosis of IBD is therefore essential. Clinical assessment, together with various imaging modalities and endoscopy, has been the mainstay of diagnosis for many years. Fecal biomarkers of gastrointestinal inflammation have appeared in the past decade, of which calprotectin, a neutrophil cytosolic protein, has been studied the most. Crohn’s disease and ulcerative colitis are chronic remitting and relapsing diseases, and objective assessment of disease activity and response to treatment are important. This review focuses on the use of fecal calprotectin measurements in the diagnosis and monitoring of patients with IBD. Keywords: calprotectin, Crohn’s disease, ulcerative colitis, inflammatory bowel disease, inflammation https://www.dovepress.com/fecal-calprotectin-in-inflammatory-bowel-disease-peer-reviewed-article-CEGcalprotectinCrohns diseaseulcerative colitisinflammatory bowel diseaseinflammation. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Walsham NE Sherwood RA |
spellingShingle |
Walsham NE Sherwood RA Fecal calprotectin in inflammatory bowel disease Clinical and Experimental Gastroenterology calprotectin Crohns disease ulcerative colitis inflammatory bowel disease inflammation. |
author_facet |
Walsham NE Sherwood RA |
author_sort |
Walsham NE |
title |
Fecal calprotectin in inflammatory bowel disease |
title_short |
Fecal calprotectin in inflammatory bowel disease |
title_full |
Fecal calprotectin in inflammatory bowel disease |
title_fullStr |
Fecal calprotectin in inflammatory bowel disease |
title_full_unstemmed |
Fecal calprotectin in inflammatory bowel disease |
title_sort |
fecal calprotectin in inflammatory bowel disease |
publisher |
Dove Medical Press |
series |
Clinical and Experimental Gastroenterology |
issn |
1178-7023 |
publishDate |
2016-01-01 |
description |
Natalie E Walsham,1 Roy A Sherwood2 1Department of Clinical Biochemistry, University Hospital Lewisham, Lewisham, 2Department of Clinical Biochemistry, Viapath at King’s College Hospital NHS Foundation Trust, London, UK Abstract: Inflammatory bowel disease (IBD) and irritable bowel syndrome share many symptoms. While irritable bowel syndrome is a functional bowel disorder for which no specific treatment is available, the range of effective therapies for IBD is evolving rapidly. Accurate diagnosis of IBD is therefore essential. Clinical assessment, together with various imaging modalities and endoscopy, has been the mainstay of diagnosis for many years. Fecal biomarkers of gastrointestinal inflammation have appeared in the past decade, of which calprotectin, a neutrophil cytosolic protein, has been studied the most. Crohn’s disease and ulcerative colitis are chronic remitting and relapsing diseases, and objective assessment of disease activity and response to treatment are important. This review focuses on the use of fecal calprotectin measurements in the diagnosis and monitoring of patients with IBD. Keywords: calprotectin, Crohn’s disease, ulcerative colitis, inflammatory bowel disease, inflammation |
topic |
calprotectin Crohns disease ulcerative colitis inflammatory bowel disease inflammation. |
url |
https://www.dovepress.com/fecal-calprotectin-in-inflammatory-bowel-disease-peer-reviewed-article-CEG |
work_keys_str_mv |
AT walshamne fecalcalprotectinininflammatoryboweldisease AT sherwoodra fecalcalprotectinininflammatoryboweldisease |
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