Intraocular Pressure Reduction Is Associated with Reduced Venous Pulsation Pressure.

PURPOSE:To explore whether alterations in intraocular pressure (IOP) affect vein pulsation properties using ophthalmodynamometric measures of vein pulsation pressure. PATIENTS AND METHODS:Glaucoma patients had two retinal vein pulsation pressure (VPP) measurements from upper and lower hemiveins perf...

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Main Authors: William H Morgan, Philip H House, Martin L Hazelton, Brigid D Betz-Stablein, Balwantray C Chauhan, Ananth Viswanathan, Dao-Yi Yu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4732770?pdf=render
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spelling doaj-d1bce73433494557a67572529be08e792020-11-24T21:50:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01111e014791510.1371/journal.pone.0147915Intraocular Pressure Reduction Is Associated with Reduced Venous Pulsation Pressure.William H MorganPhilip H HouseMartin L HazeltonBrigid D Betz-StableinBalwantray C ChauhanAnanth ViswanathanDao-Yi YuPURPOSE:To explore whether alterations in intraocular pressure (IOP) affect vein pulsation properties using ophthalmodynamometric measures of vein pulsation pressure. PATIENTS AND METHODS:Glaucoma patients had two retinal vein pulsation pressure (VPP) measurements from upper and lower hemiveins performed by ophthalmodynamometry at least 3 months apart. All subjects had VPP and IOP recorded at two visits, with standard automated perimetry, central corneal thickness (CCT) recorded at the initial visit. Where venous pulsation was spontaneous ophthalmodynamometry could not be performed and VPP was considered equal to IOP. Change in VPP was calculated and binarized with reduction in pressure scored 1 and no change or increase scored as 0. Data analysis used a mixed logistic regression model with change in VPP as response variable and change in IOP, visual field loss (mean deviation), CCT and time interval as explanatory variables. RESULTS:31 subjects (20 females) with mean age 60 years (sd 11) were examined with change in VPP being significantly associated with change in IOP (odds ratio 1.6/mmHg, 95% CI 1.2 to 2.1 in the glaucoma patients but not suspect patients (p = 0.0005). CONCLUSION:Change in VPP is strongly associated with change in IOP such that a reduced intraocular pressure is associated with a subsequent reduction in VPP. This indicates that reduced IOP alters some retinal vein properties however the nature and time course of these changes is not known.http://europepmc.org/articles/PMC4732770?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author William H Morgan
Philip H House
Martin L Hazelton
Brigid D Betz-Stablein
Balwantray C Chauhan
Ananth Viswanathan
Dao-Yi Yu
spellingShingle William H Morgan
Philip H House
Martin L Hazelton
Brigid D Betz-Stablein
Balwantray C Chauhan
Ananth Viswanathan
Dao-Yi Yu
Intraocular Pressure Reduction Is Associated with Reduced Venous Pulsation Pressure.
PLoS ONE
author_facet William H Morgan
Philip H House
Martin L Hazelton
Brigid D Betz-Stablein
Balwantray C Chauhan
Ananth Viswanathan
Dao-Yi Yu
author_sort William H Morgan
title Intraocular Pressure Reduction Is Associated with Reduced Venous Pulsation Pressure.
title_short Intraocular Pressure Reduction Is Associated with Reduced Venous Pulsation Pressure.
title_full Intraocular Pressure Reduction Is Associated with Reduced Venous Pulsation Pressure.
title_fullStr Intraocular Pressure Reduction Is Associated with Reduced Venous Pulsation Pressure.
title_full_unstemmed Intraocular Pressure Reduction Is Associated with Reduced Venous Pulsation Pressure.
title_sort intraocular pressure reduction is associated with reduced venous pulsation pressure.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2016-01-01
description PURPOSE:To explore whether alterations in intraocular pressure (IOP) affect vein pulsation properties using ophthalmodynamometric measures of vein pulsation pressure. PATIENTS AND METHODS:Glaucoma patients had two retinal vein pulsation pressure (VPP) measurements from upper and lower hemiveins performed by ophthalmodynamometry at least 3 months apart. All subjects had VPP and IOP recorded at two visits, with standard automated perimetry, central corneal thickness (CCT) recorded at the initial visit. Where venous pulsation was spontaneous ophthalmodynamometry could not be performed and VPP was considered equal to IOP. Change in VPP was calculated and binarized with reduction in pressure scored 1 and no change or increase scored as 0. Data analysis used a mixed logistic regression model with change in VPP as response variable and change in IOP, visual field loss (mean deviation), CCT and time interval as explanatory variables. RESULTS:31 subjects (20 females) with mean age 60 years (sd 11) were examined with change in VPP being significantly associated with change in IOP (odds ratio 1.6/mmHg, 95% CI 1.2 to 2.1 in the glaucoma patients but not suspect patients (p = 0.0005). CONCLUSION:Change in VPP is strongly associated with change in IOP such that a reduced intraocular pressure is associated with a subsequent reduction in VPP. This indicates that reduced IOP alters some retinal vein properties however the nature and time course of these changes is not known.
url http://europepmc.org/articles/PMC4732770?pdf=render
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