Identification of TBX2 and TBX3 variants in patients with conotruncal heart defects by target sequencing

Identification of TBX2 and TBX3 variants in patients with conotruncal heart defects by target sequencing

Abstract Background Conotruncal heart defects (CTDs) are heterogeneous congenital heart malformations that result from outflow tract dysplasia; however, the genetic determinants underlying CTDs remain unclear. Increasing evidence demonstrates that dysfunctional TBX2 and TBX3 result in outflow tract...

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Bibliographic Details
Main Authors: Huilin Xie, Erge Zhang, Nanchao Hong, Qihua Fu, Fen Li, Sun Chen, Yu Yu, Kun Sun
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Human Genomics
Subjects:
TBX2
TBX3
Variant
Conotruncal heart defects
Target sequencing
Online Access:http://link.springer.com/article/10.1186/s40246-018-0176-0

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