Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow
Memory B cells are important for protecting the host from pathogen rechallenge, but their properties and locations remain ill-defined. Here the authors show, using single-cell transcriptomics and repertoire analyses, that mouse spleen and bone marrow host distinct populations of isotype-switched mem...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16464-6 |
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doaj-d1c99a7f8c7f4d7ab186f53fdfc1db4e2021-05-23T11:14:43ZengNature Publishing GroupNature Communications2041-17232020-05-0111111410.1038/s41467-020-16464-6Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrowRené Riedel0Richard Addo1Marta Ferreira-Gomes2Gitta Anne Heinz3Frederik Heinrich4Jannis Kummer5Victor Greiff6Daniel Schulz7Cora Klaeden8Rebecca Cornelis9Ulrike Menzel10Stefan Kröger11Ulrik Stervbo12Ralf Köhler13Claudia Haftmann14Silvia Kühnel15Katrin Lehmann16Patrick Maschmeyer17Mairi McGrath18Sandra Naundorf19Stefanie Hahne20Özen Sercan-Alp21Francesco Siracusa22Jonathan Stefanowski23Melanie Weber24Kerstin Westendorf25Jakob Zimmermann26Anja E. Hauser27Sai T. Reddy28Pawel Durek29Hyun-Dong Chang30Mir-Farzin Mashreghi31Andreas Radbruch32Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDepartment of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH Zürich)Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDepartment of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH Zürich)Knowledge Management in Bioinformatics, Humboldt-Universität zu BerlinDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDepartment of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH Zürich)Deutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationDeutsches Rheuma-Forschungszentrum (DRFZ), an Institute of the Leibniz AssociationMemory B cells are important for protecting the host from pathogen rechallenge, but their properties and locations remain ill-defined. Here the authors show, using single-cell transcriptomics and repertoire analyses, that mouse spleen and bone marrow host distinct populations of isotype-switched memory B cells to potentially optimize for rapid recall responses.https://doi.org/10.1038/s41467-020-16464-6 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
René Riedel Richard Addo Marta Ferreira-Gomes Gitta Anne Heinz Frederik Heinrich Jannis Kummer Victor Greiff Daniel Schulz Cora Klaeden Rebecca Cornelis Ulrike Menzel Stefan Kröger Ulrik Stervbo Ralf Köhler Claudia Haftmann Silvia Kühnel Katrin Lehmann Patrick Maschmeyer Mairi McGrath Sandra Naundorf Stefanie Hahne Özen Sercan-Alp Francesco Siracusa Jonathan Stefanowski Melanie Weber Kerstin Westendorf Jakob Zimmermann Anja E. Hauser Sai T. Reddy Pawel Durek Hyun-Dong Chang Mir-Farzin Mashreghi Andreas Radbruch |
| spellingShingle |
René Riedel Richard Addo Marta Ferreira-Gomes Gitta Anne Heinz Frederik Heinrich Jannis Kummer Victor Greiff Daniel Schulz Cora Klaeden Rebecca Cornelis Ulrike Menzel Stefan Kröger Ulrik Stervbo Ralf Köhler Claudia Haftmann Silvia Kühnel Katrin Lehmann Patrick Maschmeyer Mairi McGrath Sandra Naundorf Stefanie Hahne Özen Sercan-Alp Francesco Siracusa Jonathan Stefanowski Melanie Weber Kerstin Westendorf Jakob Zimmermann Anja E. Hauser Sai T. Reddy Pawel Durek Hyun-Dong Chang Mir-Farzin Mashreghi Andreas Radbruch Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow Nature Communications |
| author_facet |
René Riedel Richard Addo Marta Ferreira-Gomes Gitta Anne Heinz Frederik Heinrich Jannis Kummer Victor Greiff Daniel Schulz Cora Klaeden Rebecca Cornelis Ulrike Menzel Stefan Kröger Ulrik Stervbo Ralf Köhler Claudia Haftmann Silvia Kühnel Katrin Lehmann Patrick Maschmeyer Mairi McGrath Sandra Naundorf Stefanie Hahne Özen Sercan-Alp Francesco Siracusa Jonathan Stefanowski Melanie Weber Kerstin Westendorf Jakob Zimmermann Anja E. Hauser Sai T. Reddy Pawel Durek Hyun-Dong Chang Mir-Farzin Mashreghi Andreas Radbruch |
| author_sort |
René Riedel |
| title |
Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow |
| title_short |
Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow |
| title_full |
Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow |
| title_fullStr |
Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow |
| title_full_unstemmed |
Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow |
| title_sort |
discrete populations of isotype-switched memory b lymphocytes are maintained in murine spleen and bone marrow |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-05-01 |
| description |
Memory B cells are important for protecting the host from pathogen rechallenge, but their properties and locations remain ill-defined. Here the authors show, using single-cell transcriptomics and repertoire analyses, that mouse spleen and bone marrow host distinct populations of isotype-switched memory B cells to potentially optimize for rapid recall responses. |
| url |
https://doi.org/10.1038/s41467-020-16464-6 |
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