FGF Signaling in Lung Development and Disease: Human Versus Mouse
Fibroblast growth factor 10 (FGF10) plays an important role in mouse lung development, injury, and repair. It is considered the main morphogen driving lung branching morphogenesis in rodents. While many studies have found FGF10 SNPs associated with COPD and branch variants in COPD smokers, there is...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-03-01
|
Series: | Frontiers in Genetics |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fgene.2019.00170/full |
id |
doaj-d1d0c4d0a0d1489ea4c878f41842fa39 |
---|---|
record_format |
Article |
spelling |
doaj-d1d0c4d0a0d1489ea4c878f41842fa392020-11-25T00:30:55ZengFrontiers Media S.A.Frontiers in Genetics1664-80212019-03-011010.3389/fgene.2019.00170444859FGF Signaling in Lung Development and Disease: Human Versus MouseSoula DanopoulosJessica ShiosakiDenise Al AlamFibroblast growth factor 10 (FGF10) plays an important role in mouse lung development, injury, and repair. It is considered the main morphogen driving lung branching morphogenesis in rodents. While many studies have found FGF10 SNPs associated with COPD and branch variants in COPD smokers, there is no evidence of a causative role for FGF10 or these SNPs in human lung development and pediatric lung diseases. We and others have shown divergent roles for FGF10 in mouse lung development and early human lung development. Herein, we only review the existing literature on FGF signaling in human lung development and pediatric human lung diseases, comparing what is known in mouse lung to that in human lung.https://www.frontiersin.org/article/10.3389/fgene.2019.00170/fullFGF10human lungdevelopmentdiseaseFGF signaling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Soula Danopoulos Jessica Shiosaki Denise Al Alam |
spellingShingle |
Soula Danopoulos Jessica Shiosaki Denise Al Alam FGF Signaling in Lung Development and Disease: Human Versus Mouse Frontiers in Genetics FGF10 human lung development disease FGF signaling |
author_facet |
Soula Danopoulos Jessica Shiosaki Denise Al Alam |
author_sort |
Soula Danopoulos |
title |
FGF Signaling in Lung Development and Disease: Human Versus Mouse |
title_short |
FGF Signaling in Lung Development and Disease: Human Versus Mouse |
title_full |
FGF Signaling in Lung Development and Disease: Human Versus Mouse |
title_fullStr |
FGF Signaling in Lung Development and Disease: Human Versus Mouse |
title_full_unstemmed |
FGF Signaling in Lung Development and Disease: Human Versus Mouse |
title_sort |
fgf signaling in lung development and disease: human versus mouse |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2019-03-01 |
description |
Fibroblast growth factor 10 (FGF10) plays an important role in mouse lung development, injury, and repair. It is considered the main morphogen driving lung branching morphogenesis in rodents. While many studies have found FGF10 SNPs associated with COPD and branch variants in COPD smokers, there is no evidence of a causative role for FGF10 or these SNPs in human lung development and pediatric lung diseases. We and others have shown divergent roles for FGF10 in mouse lung development and early human lung development. Herein, we only review the existing literature on FGF signaling in human lung development and pediatric human lung diseases, comparing what is known in mouse lung to that in human lung. |
topic |
FGF10 human lung development disease FGF signaling |
url |
https://www.frontiersin.org/article/10.3389/fgene.2019.00170/full |
work_keys_str_mv |
AT souladanopoulos fgfsignalinginlungdevelopmentanddiseasehumanversusmouse AT jessicashiosaki fgfsignalinginlungdevelopmentanddiseasehumanversusmouse AT denisealalam fgfsignalinginlungdevelopmentanddiseasehumanversusmouse |
_version_ |
1725324941437435904 |