Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter

Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter

Clathrin-independent endocytosis (CIE) mediates internalization of many transmembrane proteins but the mechanisms of cargo recruitment during CIE are poorly understood. We found that the cell-permeable furopyrimidine AIM-100 promotes dramatic oligomerization, clustering and CIE of human and mouse do...

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Bibliographic Details
Main Authors: Tatiana Sorkina, Shiqi Ma, Mads Breum Larsen, Simon C Watkins, Alexander Sorkin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-04-01
Series:eLife
Subjects:
dopamine trasporter
endocytosis
oligomerization
Online Access:https://elifesciences.org/articles/32293

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