Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing
Aberrant tissue repair may result in heterotopic ossification (HO), but how this process is regulated by local inflammatory responses is still unclear. Here the authors show, using a mouse burn/trauma model, that TGFβ-producing monocytes/macrophages at the injury site contribute to HO induction, whi...
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| Language: | English |
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Nature Publishing Group
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-14172-4 |
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doaj-d1da08c830104fc9b81a6525ff7ff86b2021-05-11T08:53:04ZengNature Publishing GroupNature Communications2041-17232020-02-0111111710.1038/s41467-019-14172-4Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healingMichael Sorkin0Amanda K. Huber1Charles Hwang2William F. Carson3Rajasree Menon4John Li5Kaetlin Vasquez6Chase Pagani7Nicole Patel8Shuli Li9Noelle D. Visser10Yashar Niknafs11Shawn Loder12Melissa Scola13Dylan Nycz14Katherine Gallagher15Laurie K. McCauley16Jiajia Xu17Aaron W. James18Shailesh Agarwal19Stephen Kunkel20Yuji Mishina21Benjamin Levi22Section of Plastic Surgery, Department of Surgery, University of MichiganSection of Plastic Surgery, Department of Surgery, University of MichiganSection of Plastic Surgery, Department of Surgery, University of MichiganDepartment of Pathology, University of MichiganDepartment of Computational Medicine and Bioinformatics, University of MichiganSection of Plastic Surgery, Department of Surgery, University of MichiganSection of Plastic Surgery, Department of Surgery, University of MichiganSection of Plastic Surgery, Department of Surgery, University of MichiganSection of Plastic Surgery, Department of Surgery, University of MichiganSection of Plastic Surgery, Department of Surgery, University of MichiganSection of Plastic Surgery, Department of Surgery, University of MichiganSection of Plastic Surgery, Department of Surgery, University of MichiganSection of Plastic Surgery, Department of Surgery, University of MichiganDepartment of Pathology, University of MichiganDivision of Vascular Surgery, Department of Surgery, University of MichiganDivision of Vascular Surgery, Department of Surgery, University of MichiganDepartment of Periodontics and Oral Medicine, University of MichiganDepartment of Pathology, Johns Hopkins UniversityDepartment of Pathology, Johns Hopkins UniversitySection of Plastic Surgery, Department of Surgery, University of MichiganDepartment of Pathology, University of MichiganDepartment of Biologic and Material Sciences, School of Dentistry, University of MichiganSection of Plastic Surgery, Department of Surgery, University of MichiganAberrant tissue repair may result in heterotopic ossification (HO), but how this process is regulated by local inflammatory responses is still unclear. Here the authors show, using a mouse burn/trauma model, that TGFβ-producing monocytes/macrophages at the injury site contribute to HO induction, while CD47 activation helps antagonize this process.https://doi.org/10.1038/s41467-019-14172-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Michael Sorkin Amanda K. Huber Charles Hwang William F. Carson Rajasree Menon John Li Kaetlin Vasquez Chase Pagani Nicole Patel Shuli Li Noelle D. Visser Yashar Niknafs Shawn Loder Melissa Scola Dylan Nycz Katherine Gallagher Laurie K. McCauley Jiajia Xu Aaron W. James Shailesh Agarwal Stephen Kunkel Yuji Mishina Benjamin Levi |
| spellingShingle |
Michael Sorkin Amanda K. Huber Charles Hwang William F. Carson Rajasree Menon John Li Kaetlin Vasquez Chase Pagani Nicole Patel Shuli Li Noelle D. Visser Yashar Niknafs Shawn Loder Melissa Scola Dylan Nycz Katherine Gallagher Laurie K. McCauley Jiajia Xu Aaron W. James Shailesh Agarwal Stephen Kunkel Yuji Mishina Benjamin Levi Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing Nature Communications |
| author_facet |
Michael Sorkin Amanda K. Huber Charles Hwang William F. Carson Rajasree Menon John Li Kaetlin Vasquez Chase Pagani Nicole Patel Shuli Li Noelle D. Visser Yashar Niknafs Shawn Loder Melissa Scola Dylan Nycz Katherine Gallagher Laurie K. McCauley Jiajia Xu Aaron W. James Shailesh Agarwal Stephen Kunkel Yuji Mishina Benjamin Levi |
| author_sort |
Michael Sorkin |
| title |
Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing |
| title_short |
Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing |
| title_full |
Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing |
| title_fullStr |
Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing |
| title_full_unstemmed |
Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing |
| title_sort |
regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-02-01 |
| description |
Aberrant tissue repair may result in heterotopic ossification (HO), but how this process is regulated by local inflammatory responses is still unclear. Here the authors show, using a mouse burn/trauma model, that TGFβ-producing monocytes/macrophages at the injury site contribute to HO induction, while CD47 activation helps antagonize this process. |
| url |
https://doi.org/10.1038/s41467-019-14172-4 |
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