Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC)
Anxiety is a psychological problem that often emerges during the normal course of human life. The detection of anxiety often involves a physical exam and a self-reporting questionnaire. However, these approaches have limitations, as the data might lack reliability and consistency upon application to...
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doaj-d1e94b932dcb4e10a2ffa14e9bc9f1be2020-11-24T21:20:06ZengMDPI AGSensors1424-82202017-05-01175118010.3390/s17051180s17051180Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC)Azrul Syafiq Zainol Abidin0Ruslinda A. Rahim1Mohd Khairuddin Md Arshad2Mohd Faudzi Fatin Nabilah3Chun Hong Voon4Thean-Hock Tang5Marimuthu Citartan6Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis, Kangar, Perlis 01000, MalaysiaInstitute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis, Kangar, Perlis 01000, MalaysiaInstitute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis, Kangar, Perlis 01000, MalaysiaInstitute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis, Kangar, Perlis 01000, MalaysiaInstitute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis, Kangar, Perlis 01000, MalaysiaAdvanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Kepala Batas, Penang 13200, MalaysiaAdvanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Kepala Batas, Penang 13200, MalaysiaAnxiety is a psychological problem that often emerges during the normal course of human life. The detection of anxiety often involves a physical exam and a self-reporting questionnaire. However, these approaches have limitations, as the data might lack reliability and consistency upon application to the same population over time. Furthermore, there might be varying understanding and interpretations of the particular question by the participant, which necessitating the approach of using biomarker-based measurement for stress diagnosis. The most prominent biomarker related to stress, hormone cortisol, plays a key role in the fight-or-flight situation, alters the immune response, and suppresses the digestive and the reproductive systems. We have taken the endeavour to review the available aptamer-based biosensor (aptasensor) for cortisol detection. The potential point-of-care diagnostic strategies that could be harnessed for the aptasensing of cortisol were also envisaged.http://www.mdpi.com/1424-8220/17/5/1180anxietycortisolaptasensoraptamer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Azrul Syafiq Zainol Abidin Ruslinda A. Rahim Mohd Khairuddin Md Arshad Mohd Faudzi Fatin Nabilah Chun Hong Voon Thean-Hock Tang Marimuthu Citartan |
spellingShingle |
Azrul Syafiq Zainol Abidin Ruslinda A. Rahim Mohd Khairuddin Md Arshad Mohd Faudzi Fatin Nabilah Chun Hong Voon Thean-Hock Tang Marimuthu Citartan Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC) Sensors anxiety cortisol aptasensor aptamer |
author_facet |
Azrul Syafiq Zainol Abidin Ruslinda A. Rahim Mohd Khairuddin Md Arshad Mohd Faudzi Fatin Nabilah Chun Hong Voon Thean-Hock Tang Marimuthu Citartan |
author_sort |
Azrul Syafiq Zainol Abidin |
title |
Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC) |
title_short |
Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC) |
title_full |
Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC) |
title_fullStr |
Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC) |
title_full_unstemmed |
Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC) |
title_sort |
current and potential developments of cortisol aptasensing towards point-of-care diagnostics (potc) |
publisher |
MDPI AG |
series |
Sensors |
issn |
1424-8220 |
publishDate |
2017-05-01 |
description |
Anxiety is a psychological problem that often emerges during the normal course of human life. The detection of anxiety often involves a physical exam and a self-reporting questionnaire. However, these approaches have limitations, as the data might lack reliability and consistency upon application to the same population over time. Furthermore, there might be varying understanding and interpretations of the particular question by the participant, which necessitating the approach of using biomarker-based measurement for stress diagnosis. The most prominent biomarker related to stress, hormone cortisol, plays a key role in the fight-or-flight situation, alters the immune response, and suppresses the digestive and the reproductive systems. We have taken the endeavour to review the available aptamer-based biosensor (aptasensor) for cortisol detection. The potential point-of-care diagnostic strategies that could be harnessed for the aptasensing of cortisol were also envisaged. |
topic |
anxiety cortisol aptasensor aptamer |
url |
http://www.mdpi.com/1424-8220/17/5/1180 |
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