A Rare Complication of Thymoma: Pure White Cell Aplasia in Good’s Syndrome
Pure white cell aplasia (PWCA) is a rare manifestation of thymoma. It is characterized by agranulocytosis with absent myeloid precursors in the bone marrow and normal hematopoiesis for other cell lines. Here we describe a 65-year-old female patient who presented with three days of fever and night sw...
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Hindawi Limited
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/1024670 |
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doaj-d1ea493d0efe483c8ccfa1c9d344f80b2020-11-25T01:49:08ZengHindawi LimitedCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/10246701024670A Rare Complication of Thymoma: Pure White Cell Aplasia in Good’s SyndromeKim Uy0Elizabeth Levin1Pawel Mroz2Faqian Li3Surbhi Shah4University of Minnesota, Department of Medicine, Division of Hematology, Oncology and Transplantation, Minneapolis, MN, USAUniversity of Minnesota, Department of Medicine, Division of Hematology, Oncology and Transplantation, Minneapolis, MN, USAUniversity of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, USAUniversity of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, USAUniversity of Minnesota, Department of Medicine, Division of Hematology, Oncology and Transplantation, Minneapolis, MN, USAPure white cell aplasia (PWCA) is a rare manifestation of thymoma. It is characterized by agranulocytosis with absent myeloid precursors in the bone marrow and normal hematopoiesis for other cell lines. Here we describe a 65-year-old female patient who presented with three days of fever and night sweat. Chest CT revealed an anterior mediastinal mass. A biopsy of the mass confirmed a diagnosis of thymoma mixed type A and B2. The patient developed a severe neutropenia, and her bone marrow revealed significantly decreased neutrophil-lineage cells, rare to absent B cells, and defective T cells, consistent with PWCA. Following thymectomy, a complete resolution of PWCA was achieved via multimodality therapy of intravenous immunoglobulins, granulocyte colony-stimulating factor, and immunosuppressant. This report highlights the care complexity regarding treatment choices and decision to perform thymectomy in patients presenting with PWCA.http://dx.doi.org/10.1155/2019/1024670 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kim Uy Elizabeth Levin Pawel Mroz Faqian Li Surbhi Shah |
| spellingShingle |
Kim Uy Elizabeth Levin Pawel Mroz Faqian Li Surbhi Shah A Rare Complication of Thymoma: Pure White Cell Aplasia in Good’s Syndrome Case Reports in Hematology |
| author_facet |
Kim Uy Elizabeth Levin Pawel Mroz Faqian Li Surbhi Shah |
| author_sort |
Kim Uy |
| title |
A Rare Complication of Thymoma: Pure White Cell Aplasia in Good’s Syndrome |
| title_short |
A Rare Complication of Thymoma: Pure White Cell Aplasia in Good’s Syndrome |
| title_full |
A Rare Complication of Thymoma: Pure White Cell Aplasia in Good’s Syndrome |
| title_fullStr |
A Rare Complication of Thymoma: Pure White Cell Aplasia in Good’s Syndrome |
| title_full_unstemmed |
A Rare Complication of Thymoma: Pure White Cell Aplasia in Good’s Syndrome |
| title_sort |
rare complication of thymoma: pure white cell aplasia in good’s syndrome |
| publisher |
Hindawi Limited |
| series |
Case Reports in Hematology |
| issn |
2090-6560 2090-6579 |
| publishDate |
2019-01-01 |
| description |
Pure white cell aplasia (PWCA) is a rare manifestation of thymoma. It is characterized by agranulocytosis with absent myeloid precursors in the bone marrow and normal hematopoiesis for other cell lines. Here we describe a 65-year-old female patient who presented with three days of fever and night sweat. Chest CT revealed an anterior mediastinal mass. A biopsy of the mass confirmed a diagnosis of thymoma mixed type A and B2. The patient developed a severe neutropenia, and her bone marrow revealed significantly decreased neutrophil-lineage cells, rare to absent B cells, and defective T cells, consistent with PWCA. Following thymectomy, a complete resolution of PWCA was achieved via multimodality therapy of intravenous immunoglobulins, granulocyte colony-stimulating factor, and immunosuppressant. This report highlights the care complexity regarding treatment choices and decision to perform thymectomy in patients presenting with PWCA. |
| url |
http://dx.doi.org/10.1155/2019/1024670 |
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