Mutation of Framework Residue H71 Results in Different Antibody Paratope States in Solution
Characterizing and understanding the antibody binding interface have become a pre-requisite for rational antibody design and engineering. The antigen-binding site is formed by six hypervariable loops, known as the complementarity determining regions (CDRs) and by the relative interdomain orientation...
Main Authors: | Monica L. Fernández-Quintero, Katharina B. Kroell, Florian Hofer, Jakob R. Riccabona, Klaus R. Liedl |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-03-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.630034/full |
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