Zn-Mg and Zn-Cu alloys for stenting applications: From nanoscale mechanical characterization to in vitro degradation and biocompatibility
In the recent decades, zinc (Zn) and its alloys have been drawing attention as promising candidates for bioresorbable cardiovascular stents due to its degradation rate more suitable than magnesium (Mg) and iron (Fe) alloys. However, its mechanical properties need to be improved in order to meet the...
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Language: | English |
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KeAi Communications Co., Ltd.
2021-12-01
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Series: | Bioactive Materials |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21001845 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claudia García-Mintegui Laura Catalina Córdoba Judit Buxadera-Palomero Andrea Marquina Emilio Jiménez-Piqué Maria-Pau Ginebra José Luis Cortina Marta Pegueroles |
spellingShingle |
Claudia García-Mintegui Laura Catalina Córdoba Judit Buxadera-Palomero Andrea Marquina Emilio Jiménez-Piqué Maria-Pau Ginebra José Luis Cortina Marta Pegueroles Zn-Mg and Zn-Cu alloys for stenting applications: From nanoscale mechanical characterization to in vitro degradation and biocompatibility Bioactive Materials Zinc alloys Bioresorbable metals Galvanic corrosion Nanoindentation Biocompatibility |
author_facet |
Claudia García-Mintegui Laura Catalina Córdoba Judit Buxadera-Palomero Andrea Marquina Emilio Jiménez-Piqué Maria-Pau Ginebra José Luis Cortina Marta Pegueroles |
author_sort |
Claudia García-Mintegui |
title |
Zn-Mg and Zn-Cu alloys for stenting applications: From nanoscale mechanical characterization to in vitro degradation and biocompatibility |
title_short |
Zn-Mg and Zn-Cu alloys for stenting applications: From nanoscale mechanical characterization to in vitro degradation and biocompatibility |
title_full |
Zn-Mg and Zn-Cu alloys for stenting applications: From nanoscale mechanical characterization to in vitro degradation and biocompatibility |
title_fullStr |
Zn-Mg and Zn-Cu alloys for stenting applications: From nanoscale mechanical characterization to in vitro degradation and biocompatibility |
title_full_unstemmed |
Zn-Mg and Zn-Cu alloys for stenting applications: From nanoscale mechanical characterization to in vitro degradation and biocompatibility |
title_sort |
zn-mg and zn-cu alloys for stenting applications: from nanoscale mechanical characterization to in vitro degradation and biocompatibility |
publisher |
KeAi Communications Co., Ltd. |
series |
Bioactive Materials |
issn |
2452-199X |
publishDate |
2021-12-01 |
description |
In the recent decades, zinc (Zn) and its alloys have been drawing attention as promising candidates for bioresorbable cardiovascular stents due to its degradation rate more suitable than magnesium (Mg) and iron (Fe) alloys. However, its mechanical properties need to be improved in order to meet the criteria for vascular stents. This work investigates the mechanical properties, biodegradability and biocompatibility of Zn-Mg and Zn-Cu alloys in order to determine a proper alloy composition for optimal stent performance. Nanoindentation measurements are performed to characterize the mechanical properties at the nanoscale as a function of the Zn microstructure variations induced by alloying. The biodegradation mechanisms are discussed and correlated to microstructure, mechanical performance and bacterial/cell response. Addition of Mg or Cu alloying elements refined the microstructure of Zn and enhanced yield strength (YS) and ultimate tensile strength (UTS) proportional to the volume fraction of secondary phases. Zn-1Mg showed the higher YS and UTS and better performance in terms of degradation stability in Hanks’ solution. Zn-Cu alloys presented an antibacterial effect for S. aureus controlled by diffusion mechanisms and by contact. Biocompatibility was dependent on the degradation rate and the nature of the corrosion products. |
topic |
Zinc alloys Bioresorbable metals Galvanic corrosion Nanoindentation Biocompatibility |
url |
http://www.sciencedirect.com/science/article/pii/S2452199X21001845 |
work_keys_str_mv |
AT claudiagarciamintegui znmgandzncualloysforstentingapplicationsfromnanoscalemechanicalcharacterizationtoinvitrodegradationandbiocompatibility AT lauracatalinacordoba znmgandzncualloysforstentingapplicationsfromnanoscalemechanicalcharacterizationtoinvitrodegradationandbiocompatibility AT juditbuxaderapalomero znmgandzncualloysforstentingapplicationsfromnanoscalemechanicalcharacterizationtoinvitrodegradationandbiocompatibility AT andreamarquina znmgandzncualloysforstentingapplicationsfromnanoscalemechanicalcharacterizationtoinvitrodegradationandbiocompatibility AT emiliojimenezpique znmgandzncualloysforstentingapplicationsfromnanoscalemechanicalcharacterizationtoinvitrodegradationandbiocompatibility AT mariapauginebra znmgandzncualloysforstentingapplicationsfromnanoscalemechanicalcharacterizationtoinvitrodegradationandbiocompatibility AT joseluiscortina znmgandzncualloysforstentingapplicationsfromnanoscalemechanicalcharacterizationtoinvitrodegradationandbiocompatibility AT martapegueroles znmgandzncualloysforstentingapplicationsfromnanoscalemechanicalcharacterizationtoinvitrodegradationandbiocompatibility |
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1717369016130994176 |
spelling |
doaj-d1ef6878ea2d457c91d3e18c22231b0b2021-09-25T05:09:25ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2021-12-0161244304446Zn-Mg and Zn-Cu alloys for stenting applications: From nanoscale mechanical characterization to in vitro degradation and biocompatibilityClaudia García-Mintegui0Laura Catalina Córdoba1Judit Buxadera-Palomero2Andrea Marquina3Emilio Jiménez-Piqué4Maria-Pau Ginebra5José Luis Cortina6Marta Pegueroles7Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Technical University of Catalonia (UPC), Barcelona East School of Engineering (EEBE), 08019, Barcelona, Spain; Resource Recovery and Environmental Management Group, UPC, EEBE, 08019, Barcelona, Spain; Barcelona Research Center in Multiscale Science and Engineering, UPC, EEBE, 08019, Barcelona, SpainBiomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Technical University of Catalonia (UPC), Barcelona East School of Engineering (EEBE), 08019, Barcelona, Spain; Institute for Bioengineering of Catalonia (IBEC), 08028, Barcelona, SpainBiomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Technical University of Catalonia (UPC), Barcelona East School of Engineering (EEBE), 08019, Barcelona, Spain; Barcelona Research Center in Multiscale Science and Engineering, UPC, EEBE, 08019, Barcelona, SpainBiomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Technical University of Catalonia (UPC), Barcelona East School of Engineering (EEBE), 08019, Barcelona, SpainBarcelona Research Center in Multiscale Science and Engineering, UPC, EEBE, 08019, Barcelona, Spain; Structural Integrity, Micromechanics and Reliability of Materials Group, Department of Materials Science and Engineering, UPC, EEBE, 08019, Barcelona, SpainBiomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Technical University of Catalonia (UPC), Barcelona East School of Engineering (EEBE), 08019, Barcelona, Spain; Barcelona Research Center in Multiscale Science and Engineering, UPC, EEBE, 08019, Barcelona, Spain; Institute for Bioengineering of Catalonia (IBEC), 08028, Barcelona, SpainResource Recovery and Environmental Management Group, UPC, EEBE, 08019, Barcelona, Spain; Barcelona Research Center in Multiscale Science and Engineering, UPC, EEBE, 08019, Barcelona, SpainBiomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Technical University of Catalonia (UPC), Barcelona East School of Engineering (EEBE), 08019, Barcelona, Spain; Barcelona Research Center in Multiscale Science and Engineering, UPC, EEBE, 08019, Barcelona, Spain; Corresponding author. Technical University of Catalonia (UPC), EEBE, Department of Materials Science and Engineering, Av. Eduard Maristany, 10-14, 08019, Barcelona, Spain.In the recent decades, zinc (Zn) and its alloys have been drawing attention as promising candidates for bioresorbable cardiovascular stents due to its degradation rate more suitable than magnesium (Mg) and iron (Fe) alloys. However, its mechanical properties need to be improved in order to meet the criteria for vascular stents. This work investigates the mechanical properties, biodegradability and biocompatibility of Zn-Mg and Zn-Cu alloys in order to determine a proper alloy composition for optimal stent performance. Nanoindentation measurements are performed to characterize the mechanical properties at the nanoscale as a function of the Zn microstructure variations induced by alloying. The biodegradation mechanisms are discussed and correlated to microstructure, mechanical performance and bacterial/cell response. Addition of Mg or Cu alloying elements refined the microstructure of Zn and enhanced yield strength (YS) and ultimate tensile strength (UTS) proportional to the volume fraction of secondary phases. Zn-1Mg showed the higher YS and UTS and better performance in terms of degradation stability in Hanks’ solution. Zn-Cu alloys presented an antibacterial effect for S. aureus controlled by diffusion mechanisms and by contact. Biocompatibility was dependent on the degradation rate and the nature of the corrosion products.http://www.sciencedirect.com/science/article/pii/S2452199X21001845Zinc alloysBioresorbable metalsGalvanic corrosionNanoindentationBiocompatibility |