EGF and TGF-𝛽1 Effects on Thyroid Function
Normal epithelial thyroid cells in culture are inhibited by TGF-𝛽1. Instead, transformed thyroid cell lines are frequently resistant to its growth inhibitory effect. Loss of TGF-𝛽 responsiveness could be due to a reduced expression of TGF-𝛽 receptors, as shown in transformed rat thyroid cell lines a...
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Series: | Journal of Thyroid Research |
Online Access: | http://dx.doi.org/10.4061/2011/431718 |
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doaj-d1f054c327fa45e996f48f65ae9a0d482020-11-24T23:14:26ZengHindawi LimitedJournal of Thyroid Research2042-00722011-01-01201110.4061/2011/431718431718EGF and TGF-𝛽1 Effects on Thyroid FunctionGabriella Mincione0Maria Carmela Di Marcantonio1Chiara Tarantelli2Sonia D'Inzeo3Arianna Nicolussi4Francesco Nardi5Caterina Francesca Donini6Anna Coppa7Department of Oncology and Experimental Medicine, University “G. d'Annunzio” Chieti-Pescara, 66013 Chieti, ItalyDepartment of Oncology and Experimental Medicine, University “G. d'Annunzio” Chieti-Pescara, 66013 Chieti, ItalyDepartment of Oncology and Experimental Medicine, University “G. d'Annunzio” Chieti-Pescara, 66013 Chieti, ItalyDepartment of Experimental Medicine and Department of Radiological Sciences Oncology and Anatomical Pathology, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Rome, ItalyDepartment of Experimental Medicine and Department of Radiological Sciences Oncology and Anatomical Pathology, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Rome, ItalyDepartment of Experimental Medicine and Department of Radiological Sciences Oncology and Anatomical Pathology, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Rome, ItalyDepartment of Experimental Medicine and Department of Radiological Sciences Oncology and Anatomical Pathology, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Rome, ItalyDepartment of Experimental Medicine and Department of Radiological Sciences Oncology and Anatomical Pathology, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Rome, ItalyNormal epithelial thyroid cells in culture are inhibited by TGF-𝛽1. Instead, transformed thyroid cell lines are frequently resistant to its growth inhibitory effect. Loss of TGF-𝛽 responsiveness could be due to a reduced expression of TGF-𝛽 receptors, as shown in transformed rat thyroid cell lines and in human thyroid tumors, or to alterations of other genes controlling TGF-𝛽 signal transduction pathway. However, in thyroid neoplasia, a complex pattern of alterations occurring during transformation and progression has been identified. Functionally, TGF-𝛽1 acts as a tumor suppressor in the early stage of transformation or as a tumor promoter in advanced cancer. This peculiar pleiotropic behaviour of TGF-𝛽 may result from cross-talk with signalling pathways mediated by other growth factors, among which EGF-like ligands play an important role. This paper reports evidences on TGF-𝛽1 and EGF systems in thyroid tumors and on the cross-talk between these growth factors in thyroid cancer.http://dx.doi.org/10.4061/2011/431718 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gabriella Mincione Maria Carmela Di Marcantonio Chiara Tarantelli Sonia D'Inzeo Arianna Nicolussi Francesco Nardi Caterina Francesca Donini Anna Coppa |
spellingShingle |
Gabriella Mincione Maria Carmela Di Marcantonio Chiara Tarantelli Sonia D'Inzeo Arianna Nicolussi Francesco Nardi Caterina Francesca Donini Anna Coppa EGF and TGF-𝛽1 Effects on Thyroid Function Journal of Thyroid Research |
author_facet |
Gabriella Mincione Maria Carmela Di Marcantonio Chiara Tarantelli Sonia D'Inzeo Arianna Nicolussi Francesco Nardi Caterina Francesca Donini Anna Coppa |
author_sort |
Gabriella Mincione |
title |
EGF and TGF-𝛽1 Effects on Thyroid Function |
title_short |
EGF and TGF-𝛽1 Effects on Thyroid Function |
title_full |
EGF and TGF-𝛽1 Effects on Thyroid Function |
title_fullStr |
EGF and TGF-𝛽1 Effects on Thyroid Function |
title_full_unstemmed |
EGF and TGF-𝛽1 Effects on Thyroid Function |
title_sort |
egf and tgf-𝛽1 effects on thyroid function |
publisher |
Hindawi Limited |
series |
Journal of Thyroid Research |
issn |
2042-0072 |
publishDate |
2011-01-01 |
description |
Normal epithelial thyroid cells in culture are inhibited by TGF-𝛽1. Instead, transformed thyroid cell lines are frequently resistant to its growth inhibitory effect. Loss of TGF-𝛽 responsiveness could be due to a reduced expression of TGF-𝛽 receptors, as shown in transformed rat thyroid cell lines and in human thyroid tumors, or to alterations of other genes controlling TGF-𝛽 signal transduction pathway. However, in thyroid neoplasia, a complex pattern of alterations occurring during transformation and progression has been identified. Functionally, TGF-𝛽1 acts as a tumor suppressor in the early stage of transformation or as a tumor promoter in advanced cancer. This peculiar pleiotropic behaviour of TGF-𝛽 may result from cross-talk with signalling pathways mediated by other growth factors, among which EGF-like ligands play an important role. This paper reports evidences on TGF-𝛽1 and EGF systems in thyroid tumors and on the cross-talk between these growth factors in thyroid cancer. |
url |
http://dx.doi.org/10.4061/2011/431718 |
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