Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1.

Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1.

ABCA7, a close relative of ABCA1 which facilitates cholesterol efflux to lipid-poor apoproteins, has been implicated in macrophage lipid efflux and clearance of apoptotic cells in in vitro studies. In the current study, we investigated the in vivo effects of macrophage ABCA7 deficiency on lipid meta...

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Main Authors: Illiana Meurs, Laura Calpe-Berdiel, Kim L L Habets, Ying Zhao, Suzanne J A Korporaal, A Mieke Mommaas, Emmanuelle Josselin, Reeni B Hildebrand, Dan Ye, Ruud Out, Johan Kuiper, Theo J C Van Berkel, Giovanna Chimini, Miranda Van Eck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3293875?pdf=render

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