Metabolic syndrome and the incidence of lung cancer: a meta-analysis of cohort studies
Abstract Background Metabolic syndrome (MetS) has been related to the pathogenesis of variety categories of cancers. This meta-analysis aimed to determine the association between MetS and the incidence of lung cancer. Methods Relevant cohort studies were identified by search of PubMed, Embase, and C...
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doaj-d1fc611eb6e14d4fbc50b55af3da236a2020-11-25T04:02:07ZengBMCDiabetology & Metabolic Syndrome1758-59962020-10-0112111110.1186/s13098-020-00598-0Metabolic syndrome and the incidence of lung cancer: a meta-analysis of cohort studiesLi Qiao0Deliang Ma1Hui Lv2Ding Shi3Min Fei4Yu Chen5Fei Xie6Zhuoyan Wang7Ying Wang8Wanhua Liang9Peiying Hu10Department of Oncology, Linyi Central HospitalDepartment of Oncology, Linyi Central HospitalHealth Promotion Center, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical CollegeState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, College of Medicine, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang UniversityHealth Promotion Center, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical CollegeHealth Promotion Center, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical CollegeHealth Promotion Center, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical CollegeHealth Promotion Center, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical CollegeHealth Promotion Center, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical CollegeDepartment of Oncology, Linyi Central HospitalHealth Promotion Center, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical CollegeAbstract Background Metabolic syndrome (MetS) has been related to the pathogenesis of variety categories of cancers. This meta-analysis aimed to determine the association between MetS and the incidence of lung cancer. Methods Relevant cohort studies were identified by search of PubMed, Embase, and Cochrane’s Library databases. Cochrane’s Q test and I2 statistic were used to analyze the heterogeneity. Random-effect model which incorporates the potential heterogeneity was used for the meta-analysis. Results Five cohort studies with 188,970 participants were included. A total of 1,295 lung cancer cases occurred during follow-up. Meta-analyses showed that neither MetS defined by the revised NCEP-ATP III criteria (hazard ratio [HR]: 0.94, 95% confidence interval [CI]: 0.84 to 1.05, p = 0.25; I2 = 0) nor the IDF criteria (HR: 0.82, 95% CI: 0.61 to 1.11, p = 0.20; I2 = 0) was associated with an affected risk of lung cancer. Subgroup analyses showed consistent results in women and in men, in studies performed in Asian and non-Asian countries, and in prospective and retrospective cohorts (p all > 0.05). Meta-analysis limited to studies with the adjustment of smoking status also showed similar results (HR: 0.91, 95% CI: 0.80 to 1.05, p = 0.21; I2 = 0). No publication bias was detected based on the Egger regression test (p = 0.32). Conclusions Current evidence from cohort studies does not support that MetS is an independent risk factor for the incidence of lung cancer.http://link.springer.com/article/10.1186/s13098-020-00598-0Metabolic syndromeLung cancerCohort studyMeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li Qiao Deliang Ma Hui Lv Ding Shi Min Fei Yu Chen Fei Xie Zhuoyan Wang Ying Wang Wanhua Liang Peiying Hu |
spellingShingle |
Li Qiao Deliang Ma Hui Lv Ding Shi Min Fei Yu Chen Fei Xie Zhuoyan Wang Ying Wang Wanhua Liang Peiying Hu Metabolic syndrome and the incidence of lung cancer: a meta-analysis of cohort studies Diabetology & Metabolic Syndrome Metabolic syndrome Lung cancer Cohort study Meta-analysis |
author_facet |
Li Qiao Deliang Ma Hui Lv Ding Shi Min Fei Yu Chen Fei Xie Zhuoyan Wang Ying Wang Wanhua Liang Peiying Hu |
author_sort |
Li Qiao |
title |
Metabolic syndrome and the incidence of lung cancer: a meta-analysis of cohort studies |
title_short |
Metabolic syndrome and the incidence of lung cancer: a meta-analysis of cohort studies |
title_full |
Metabolic syndrome and the incidence of lung cancer: a meta-analysis of cohort studies |
title_fullStr |
Metabolic syndrome and the incidence of lung cancer: a meta-analysis of cohort studies |
title_full_unstemmed |
Metabolic syndrome and the incidence of lung cancer: a meta-analysis of cohort studies |
title_sort |
metabolic syndrome and the incidence of lung cancer: a meta-analysis of cohort studies |
publisher |
BMC |
series |
Diabetology & Metabolic Syndrome |
issn |
1758-5996 |
publishDate |
2020-10-01 |
description |
Abstract Background Metabolic syndrome (MetS) has been related to the pathogenesis of variety categories of cancers. This meta-analysis aimed to determine the association between MetS and the incidence of lung cancer. Methods Relevant cohort studies were identified by search of PubMed, Embase, and Cochrane’s Library databases. Cochrane’s Q test and I2 statistic were used to analyze the heterogeneity. Random-effect model which incorporates the potential heterogeneity was used for the meta-analysis. Results Five cohort studies with 188,970 participants were included. A total of 1,295 lung cancer cases occurred during follow-up. Meta-analyses showed that neither MetS defined by the revised NCEP-ATP III criteria (hazard ratio [HR]: 0.94, 95% confidence interval [CI]: 0.84 to 1.05, p = 0.25; I2 = 0) nor the IDF criteria (HR: 0.82, 95% CI: 0.61 to 1.11, p = 0.20; I2 = 0) was associated with an affected risk of lung cancer. Subgroup analyses showed consistent results in women and in men, in studies performed in Asian and non-Asian countries, and in prospective and retrospective cohorts (p all > 0.05). Meta-analysis limited to studies with the adjustment of smoking status also showed similar results (HR: 0.91, 95% CI: 0.80 to 1.05, p = 0.21; I2 = 0). No publication bias was detected based on the Egger regression test (p = 0.32). Conclusions Current evidence from cohort studies does not support that MetS is an independent risk factor for the incidence of lung cancer. |
topic |
Metabolic syndrome Lung cancer Cohort study Meta-analysis |
url |
http://link.springer.com/article/10.1186/s13098-020-00598-0 |
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