Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China
Abstract Background Previous studies have focused on the clinical characteristics of hospitalized patients with the novel 2019 coronavirus disease (COVID-19). Limited data are available for convalescent patients. This study aimed to evaluate the clinical characteristics of discharged COVID-19 patien...
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doaj-d200503e012b465d8f3f914055f0c2f82020-11-26T12:50:41ZengBMCRespiratory Research1465-993X2020-11-0121111010.1186/s12931-020-01580-0Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, ChinaSiqin Zhang0Lin Liu1Bin Yang2Rou Li3Jianhua Luo4Jing Huang5Yanjun Long6Ying Huang7Jianping Zhou8Yan Zha9Xiangyan Zhang10Department of Endocrinology and Metabolism, Guizhou Provincial People’s HospitalDepartment of Respiratory and Critical Medicine, Guizhou Provincial People’s HospitalDepartment of Central Laboratory, Guizhou Provincial People’s HospitalSchool of Medicine, Guizhou UniversityDepartment of Endocrinology and Metabolism, Guizhou Provincial People’s HospitalDepartment of Cardiology, Guizhou Provincial People’s HospitalDepartment of Nephrology, Institute of Nephritic and Urinary Disease, Guizhou Provincial People’s HospitalDepartment of Psychology, Guizhou Provincial People’s HospitalDepartment of Pediatrics, Guizhou Provincial People’s HospitalDepartment of Nephrology, Institute of Nephritic and Urinary Disease, Guizhou Provincial People’s HospitalDepartment of Respiratory and Critical Medicine, Guizhou Provincial People’s HospitalAbstract Background Previous studies have focused on the clinical characteristics of hospitalized patients with the novel 2019 coronavirus disease (COVID-19). Limited data are available for convalescent patients. This study aimed to evaluate the clinical characteristics of discharged COVID-19 patients. Methods In this retrospective study, we extracted data for 134 convalescent patients with COVID-19 in Guizhou Provincial Staff Hospital from February 15 to March 31, 2020. Cases were analyzed on the basis of demographic, clinical, and laboratory data as well as radiological features. Results Of 134 convalescent patients with COVID-19, 19 (14.2%) were severe cases, while 115 (85.8%) were non-severe cases. The median patient age was 33 years (IQR, 21.8 to 46.3), and the cohort included 69 men and 65 women. Compared with non-severe cases, severe patients were older and had more chronic comorbidities, especially hypertension, diabetes, and thyroid disease (P < 0.05). Leukopenia was present in 32.1% of the convalescent patients and lymphocytopenia was present in 6.7%, both of which were more common in severe patients. 48 (35.8%) of discharged patients had elevated levels of alanine aminotransferase, which was more common in adults than in children (40.2% vs 13.6%, P = 0.018). A normal chest CT was found in 61 (45.5%) patients during rehabilitation. Severe patients had more ground-glass opacity, bilateral patchy shadowing, and fibrosis. No significant differences were observed in the positive rate of IgG and/or IgM antibodies between severe and non-severe patients. Conclusion Leukopenia, lymphopenia, ground-glass opacity, and fibrosis are common in discharged severe COVID-19 patients, and liver injury is common in discharged adult patients. We suggest physicians develop follow-up treatment plans based on the different clinical characteristics of convalescent patients.http://link.springer.com/article/10.1186/s12931-020-01580-0Coronavirus disease 2019 (COVID-19)Clinical featuresDisease severityPneumonia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Siqin Zhang Lin Liu Bin Yang Rou Li Jianhua Luo Jing Huang Yanjun Long Ying Huang Jianping Zhou Yan Zha Xiangyan Zhang |
spellingShingle |
Siqin Zhang Lin Liu Bin Yang Rou Li Jianhua Luo Jing Huang Yanjun Long Ying Huang Jianping Zhou Yan Zha Xiangyan Zhang Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China Respiratory Research Coronavirus disease 2019 (COVID-19) Clinical features Disease severity Pneumonia |
author_facet |
Siqin Zhang Lin Liu Bin Yang Rou Li Jianhua Luo Jing Huang Yanjun Long Ying Huang Jianping Zhou Yan Zha Xiangyan Zhang |
author_sort |
Siqin Zhang |
title |
Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China |
title_short |
Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China |
title_full |
Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China |
title_fullStr |
Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China |
title_full_unstemmed |
Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China |
title_sort |
clinical characteristics of 134 convalescent patients with covid-19 in guizhou, china |
publisher |
BMC |
series |
Respiratory Research |
issn |
1465-993X |
publishDate |
2020-11-01 |
description |
Abstract Background Previous studies have focused on the clinical characteristics of hospitalized patients with the novel 2019 coronavirus disease (COVID-19). Limited data are available for convalescent patients. This study aimed to evaluate the clinical characteristics of discharged COVID-19 patients. Methods In this retrospective study, we extracted data for 134 convalescent patients with COVID-19 in Guizhou Provincial Staff Hospital from February 15 to March 31, 2020. Cases were analyzed on the basis of demographic, clinical, and laboratory data as well as radiological features. Results Of 134 convalescent patients with COVID-19, 19 (14.2%) were severe cases, while 115 (85.8%) were non-severe cases. The median patient age was 33 years (IQR, 21.8 to 46.3), and the cohort included 69 men and 65 women. Compared with non-severe cases, severe patients were older and had more chronic comorbidities, especially hypertension, diabetes, and thyroid disease (P < 0.05). Leukopenia was present in 32.1% of the convalescent patients and lymphocytopenia was present in 6.7%, both of which were more common in severe patients. 48 (35.8%) of discharged patients had elevated levels of alanine aminotransferase, which was more common in adults than in children (40.2% vs 13.6%, P = 0.018). A normal chest CT was found in 61 (45.5%) patients during rehabilitation. Severe patients had more ground-glass opacity, bilateral patchy shadowing, and fibrosis. No significant differences were observed in the positive rate of IgG and/or IgM antibodies between severe and non-severe patients. Conclusion Leukopenia, lymphopenia, ground-glass opacity, and fibrosis are common in discharged severe COVID-19 patients, and liver injury is common in discharged adult patients. We suggest physicians develop follow-up treatment plans based on the different clinical characteristics of convalescent patients. |
topic |
Coronavirus disease 2019 (COVID-19) Clinical features Disease severity Pneumonia |
url |
http://link.springer.com/article/10.1186/s12931-020-01580-0 |
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