Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research
Background: Emerging evidence implicates the dysregulated kynurenine pathway (KP), an immune-inflammatory pathway, in the pathophysiology of mood disorders (MD), including depression and bipolar disorder characterized by a low-grade chronic pro-inflammatory state. The metabolites of the KP, an impor...
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Frontiers Media S.A.
2021-06-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.687757/full |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiuqing Zhu Xiuqing Zhu Jinqing Hu Jinqing Hu Shuhua Deng Shuhua Deng Yaqian Tan Yaqian Tan Chang Qiu Chang Qiu Ming Zhang Ming Zhang Xiaojia Ni Xiaojia Ni Haoyang Lu Haoyang Lu Zhanzhang Wang Zhanzhang Wang Lu Li Lu Li Yayan Luo Yayan Luo Shanqing Huang Tao Xiao Shujing Liu Xiaolin Li Dewei Shang Dewei Shang Yuguan Wen Yuguan Wen |
spellingShingle |
Xiuqing Zhu Xiuqing Zhu Jinqing Hu Jinqing Hu Shuhua Deng Shuhua Deng Yaqian Tan Yaqian Tan Chang Qiu Chang Qiu Ming Zhang Ming Zhang Xiaojia Ni Xiaojia Ni Haoyang Lu Haoyang Lu Zhanzhang Wang Zhanzhang Wang Lu Li Lu Li Yayan Luo Yayan Luo Shanqing Huang Tao Xiao Shujing Liu Xiaolin Li Dewei Shang Dewei Shang Yuguan Wen Yuguan Wen Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research Frontiers in Pharmacology kynurenine pathway mood disorders depression bipolar disorder bibliometric analysis gut microbiota |
author_facet |
Xiuqing Zhu Xiuqing Zhu Jinqing Hu Jinqing Hu Shuhua Deng Shuhua Deng Yaqian Tan Yaqian Tan Chang Qiu Chang Qiu Ming Zhang Ming Zhang Xiaojia Ni Xiaojia Ni Haoyang Lu Haoyang Lu Zhanzhang Wang Zhanzhang Wang Lu Li Lu Li Yayan Luo Yayan Luo Shanqing Huang Tao Xiao Shujing Liu Xiaolin Li Dewei Shang Dewei Shang Yuguan Wen Yuguan Wen |
author_sort |
Xiuqing Zhu |
title |
Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research |
title_short |
Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research |
title_full |
Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research |
title_fullStr |
Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research |
title_full_unstemmed |
Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research |
title_sort |
comprehensive bibliometric analysis of the kynurenine pathway in mood disorders: focus on gut microbiota research |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2021-06-01 |
description |
Background: Emerging evidence implicates the dysregulated kynurenine pathway (KP), an immune-inflammatory pathway, in the pathophysiology of mood disorders (MD), including depression and bipolar disorder characterized by a low-grade chronic pro-inflammatory state. The metabolites of the KP, an important part of the microbiota-gut-brain axis, serve as immune system modulators linking the gut microbiota (GM) with the host central nervous system.Aim: This bibliometric analysis aimed to provide a first glimpse into the KP in MD, with a focus on GM research in this field, to guide future research and promote the development of this field.Methods: Publications relating to the KP in MD between the years 2000 and 2020 were retrieved from the Scopus and Web of Science Core Collection (WoSCC), and analyzed in CiteSpace (5.7 R5W), biblioshiny (using R-Studio), and VOSviewer (1.6.16).Results: In total, 1,064 and 948 documents were extracted from the Scopus and WoSCC databases, respectively. The publications have shown rapid growth since 2006, partly owing to the largest research hotspot appearing since then, “quinolinic acid.” All the top five most relevant journals were in the neuropsychiatry field, such as Brain Behavior and Immunity. The United States and Innsbruck Medical University were the most influential country and institute, respectively. Journal co-citation analysis showed a strong tendency toward co-citation of research in the psychiatry field. Reference co-citation analysis revealed that the top four most important research focuses were “kynurenine pathway,” “psychoneuroimmunology,” “indoleamine 2,3-dioxygenase,” and “proinflammatory cytokines,” and the most recent focus was “gut-brain axis,” thus indicating the role of the KP in bridging the GM and the host immune system, and together reflecting the field’s research foundations. Overlap analysis between the thematic map of keywords and the keyword burst analysis revealed that the topics “Alzheimer’s disease,” “prefrontal cortex,” and “acid,” were research frontiers.Conclusion: This comprehensive bibliometric study provides an updated perspective on research associated with the KP in MD, with a focus on the current status of GM research in this field. This perspective may benefit researchers in choosing suitable journals and collaborators, and aid in the further understanding of the field’s hotspots and frontiers, thus facilitating future research. |
topic |
kynurenine pathway mood disorders depression bipolar disorder bibliometric analysis gut microbiota |
url |
https://www.frontiersin.org/articles/10.3389/fphar.2021.687757/full |
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doaj-d2071d6fddcb4776b19d1ce381e27f952021-06-22T06:03:54ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-06-011210.3389/fphar.2021.687757687757Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota ResearchXiuqing Zhu0Xiuqing Zhu1Jinqing Hu2Jinqing Hu3Shuhua Deng4Shuhua Deng5Yaqian Tan6Yaqian Tan7Chang Qiu8Chang Qiu9Ming Zhang10Ming Zhang11Xiaojia Ni12Xiaojia Ni13Haoyang Lu14Haoyang Lu15Zhanzhang Wang16Zhanzhang Wang17Lu Li18Lu Li19Yayan Luo20Yayan Luo21Shanqing Huang22Tao Xiao23Shujing Liu24Xiaolin Li25Dewei Shang26Dewei Shang27Yuguan Wen28Yuguan Wen29Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaGuangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaGuangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaGuangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaGuangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaGuangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaGuangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaGuangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaGuangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaGuangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaGuangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, ChinaGuangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, ChinaInstitute of Neuropsychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaGuangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, ChinaDepartment of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, ChinaGuangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, ChinaBackground: Emerging evidence implicates the dysregulated kynurenine pathway (KP), an immune-inflammatory pathway, in the pathophysiology of mood disorders (MD), including depression and bipolar disorder characterized by a low-grade chronic pro-inflammatory state. The metabolites of the KP, an important part of the microbiota-gut-brain axis, serve as immune system modulators linking the gut microbiota (GM) with the host central nervous system.Aim: This bibliometric analysis aimed to provide a first glimpse into the KP in MD, with a focus on GM research in this field, to guide future research and promote the development of this field.Methods: Publications relating to the KP in MD between the years 2000 and 2020 were retrieved from the Scopus and Web of Science Core Collection (WoSCC), and analyzed in CiteSpace (5.7 R5W), biblioshiny (using R-Studio), and VOSviewer (1.6.16).Results: In total, 1,064 and 948 documents were extracted from the Scopus and WoSCC databases, respectively. The publications have shown rapid growth since 2006, partly owing to the largest research hotspot appearing since then, “quinolinic acid.” All the top five most relevant journals were in the neuropsychiatry field, such as Brain Behavior and Immunity. The United States and Innsbruck Medical University were the most influential country and institute, respectively. Journal co-citation analysis showed a strong tendency toward co-citation of research in the psychiatry field. Reference co-citation analysis revealed that the top four most important research focuses were “kynurenine pathway,” “psychoneuroimmunology,” “indoleamine 2,3-dioxygenase,” and “proinflammatory cytokines,” and the most recent focus was “gut-brain axis,” thus indicating the role of the KP in bridging the GM and the host immune system, and together reflecting the field’s research foundations. Overlap analysis between the thematic map of keywords and the keyword burst analysis revealed that the topics “Alzheimer’s disease,” “prefrontal cortex,” and “acid,” were research frontiers.Conclusion: This comprehensive bibliometric study provides an updated perspective on research associated with the KP in MD, with a focus on the current status of GM research in this field. This perspective may benefit researchers in choosing suitable journals and collaborators, and aid in the further understanding of the field’s hotspots and frontiers, thus facilitating future research.https://www.frontiersin.org/articles/10.3389/fphar.2021.687757/fullkynurenine pathwaymood disordersdepressionbipolar disorderbibliometric analysisgut microbiota |