Anorexia Nervosa and the Immune System—A Narrative Review
The pathogenesis of an increasing number of chronic diseases is being attributed to effects of the immune system. However, its role in the development and maintenance of anorexia nervosa is seemingly under-appreciated. Yet, in examining the available research on the immune system and genetic studies...
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doaj-d20904654bb74702ba899481b5f8cfaf2020-11-25T00:04:56ZengMDPI AGJournal of Clinical Medicine2077-03832019-11-01811191510.3390/jcm8111915jcm8111915Anorexia Nervosa and the Immune System—A Narrative ReviewDennis Gibson0Philip S Mehler1Assistant Medical Director, ACUTE Center for Eating Disorders @ Denver Health; Assistant Professor of Medicine, University of Colorado School of Medicine; 777 Bannock St., Denver, CO 80204, USAPresident, Eating Recovery Center; Founder and Executive Medical Director, ACUTE Center for Eating Disorders @ Denver Health; Glassman Professor of Medicine, University of Colorado School of Medicine; 7351 E Lowry Blvd, Suite 200, Denver, CO 80230, USAThe pathogenesis of an increasing number of chronic diseases is being attributed to effects of the immune system. However, its role in the development and maintenance of anorexia nervosa is seemingly under-appreciated. Yet, in examining the available research on the immune system and genetic studies in anorexia nervosa, one becomes increasingly suspicious of the immune system’s potential role in the pathophysiology of anorexia nervosa. Specifically, research is suggestive of increased levels of various pro-inflammatory cytokines as well as the spontaneous production of tumor necrosis factor in anorexia nervosa; genetic studies further support a dysregulated immune system in this disorder. Potential contributors to this dysregulated immune system are discussed including increased oxidative stress, chronic physiological/psychological stress, changes in the intestinal microbiota, and an abnormal bone marrow microenvironment, all of which are present in anorexia nervosa.https://www.mdpi.com/2077-0383/8/11/1915anorexia nervosaeating disordersimmune systeminflammationcytokines |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dennis Gibson Philip S Mehler |
spellingShingle |
Dennis Gibson Philip S Mehler Anorexia Nervosa and the Immune System—A Narrative Review Journal of Clinical Medicine anorexia nervosa eating disorders immune system inflammation cytokines |
author_facet |
Dennis Gibson Philip S Mehler |
author_sort |
Dennis Gibson |
title |
Anorexia Nervosa and the Immune System—A Narrative Review |
title_short |
Anorexia Nervosa and the Immune System—A Narrative Review |
title_full |
Anorexia Nervosa and the Immune System—A Narrative Review |
title_fullStr |
Anorexia Nervosa and the Immune System—A Narrative Review |
title_full_unstemmed |
Anorexia Nervosa and the Immune System—A Narrative Review |
title_sort |
anorexia nervosa and the immune system—a narrative review |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-11-01 |
description |
The pathogenesis of an increasing number of chronic diseases is being attributed to effects of the immune system. However, its role in the development and maintenance of anorexia nervosa is seemingly under-appreciated. Yet, in examining the available research on the immune system and genetic studies in anorexia nervosa, one becomes increasingly suspicious of the immune system’s potential role in the pathophysiology of anorexia nervosa. Specifically, research is suggestive of increased levels of various pro-inflammatory cytokines as well as the spontaneous production of tumor necrosis factor in anorexia nervosa; genetic studies further support a dysregulated immune system in this disorder. Potential contributors to this dysregulated immune system are discussed including increased oxidative stress, chronic physiological/psychological stress, changes in the intestinal microbiota, and an abnormal bone marrow microenvironment, all of which are present in anorexia nervosa. |
topic |
anorexia nervosa eating disorders immune system inflammation cytokines |
url |
https://www.mdpi.com/2077-0383/8/11/1915 |
work_keys_str_mv |
AT dennisgibson anorexianervosaandtheimmunesystemanarrativereview AT philipsmehler anorexianervosaandtheimmunesystemanarrativereview |
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