Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease
Objectives. To explore effectiveness and mechanisms of electroacupuncture (EA) add-on treatment in Parkinson’s disease (PD) patients. Methods. Fifty PD patients were randomly assigned to drug plus EA (D + EA) group and drug alone (D) group. Subjects in D + EA group received stimulation in points of...
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doaj-d20b60237545498998d1ddec51e52afd2020-11-24T22:26:50ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882015-01-01201510.1155/2015/692795692795Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s DiseaseFang Wang0Li Sun1Xiao-zhe Zhang2Jun Jia3Zhuo Liu4Xi-yan Huang5Shu-yang Yu6Li-jun Zuo7Chen-jie Cao8Xiao-min Wang9Wei Zhang10Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Acupuncture, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Physiology, Capital Medical University, Beijing 100069, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Physiology, Capital Medical University, Beijing 100069, ChinaDepartment of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, ChinaObjectives. To explore effectiveness and mechanisms of electroacupuncture (EA) add-on treatment in Parkinson’s disease (PD) patients. Methods. Fifty PD patients were randomly assigned to drug plus EA (D + EA) group and drug alone (D) group. Subjects in D + EA group received stimulation in points of bilateral fengfu, fengchi, hegu, and central dazhui. Participants were evaluated by scales for motor and nonmotor symptoms. Levels of neuroinflammatory factors and neurotransmitters in serum were detected. Results. EA add-on treatment remarkably reduced scores of Unified Parkinson’s Disease Rating Scale (UPDRS) III and its subitems of tremor, rigidity, and bradykinesia and conspicuously decreased UPDRS III scores in patients with bradykinesia-rigidity and mixed types and mild severity. Depression and sleep disturbances were eased, which were reflected by decreased scores of Hamilton Depression Rating Scale, Pittsburgh Sleep Quality Index, and elevated noradrenaline level. Effects of EA add-on treatment on motor symptoms and sleep disturbances were superior to drug alone treatment, markedly improving life quality of PD patients. EA add-on treatment decreased nitric oxide level in serum. Conclusions. EA add-on treatment is effective on most motor symptoms and some nonmotor symptoms and is particularly efficacious in PD patients at early stage. Antineuroinflammation may be a mechanism of EA add-on treatment.http://dx.doi.org/10.1155/2015/692795 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fang Wang Li Sun Xiao-zhe Zhang Jun Jia Zhuo Liu Xi-yan Huang Shu-yang Yu Li-jun Zuo Chen-jie Cao Xiao-min Wang Wei Zhang |
spellingShingle |
Fang Wang Li Sun Xiao-zhe Zhang Jun Jia Zhuo Liu Xi-yan Huang Shu-yang Yu Li-jun Zuo Chen-jie Cao Xiao-min Wang Wei Zhang Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease Evidence-Based Complementary and Alternative Medicine |
author_facet |
Fang Wang Li Sun Xiao-zhe Zhang Jun Jia Zhuo Liu Xi-yan Huang Shu-yang Yu Li-jun Zuo Chen-jie Cao Xiao-min Wang Wei Zhang |
author_sort |
Fang Wang |
title |
Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease |
title_short |
Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease |
title_full |
Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease |
title_fullStr |
Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease |
title_full_unstemmed |
Effect and Potential Mechanism of Electroacupuncture Add-On Treatment in Patients with Parkinson’s Disease |
title_sort |
effect and potential mechanism of electroacupuncture add-on treatment in patients with parkinson’s disease |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2015-01-01 |
description |
Objectives. To explore effectiveness and mechanisms of electroacupuncture (EA) add-on treatment in Parkinson’s disease (PD) patients. Methods. Fifty PD patients were randomly assigned to drug plus EA (D + EA) group and drug alone (D) group. Subjects in D + EA group received stimulation in points of bilateral fengfu, fengchi, hegu, and central dazhui. Participants were evaluated by scales for motor and nonmotor symptoms. Levels of neuroinflammatory factors and neurotransmitters in serum were detected. Results. EA add-on treatment remarkably reduced scores of Unified Parkinson’s Disease Rating Scale (UPDRS) III and its subitems of tremor, rigidity, and bradykinesia and conspicuously decreased UPDRS III scores in patients with bradykinesia-rigidity and mixed types and mild severity. Depression and sleep disturbances were eased, which were reflected by decreased scores of Hamilton Depression Rating Scale, Pittsburgh Sleep Quality Index, and elevated noradrenaline level. Effects of EA add-on treatment on motor symptoms and sleep disturbances were superior to drug alone treatment, markedly improving life quality of PD patients. EA add-on treatment decreased nitric oxide level in serum. Conclusions. EA add-on treatment is effective on most motor symptoms and some nonmotor symptoms and is particularly efficacious in PD patients at early stage. Antineuroinflammation may be a mechanism of EA add-on treatment. |
url |
http://dx.doi.org/10.1155/2015/692795 |
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