The amino acid substitution Q65H in the 2C protein of swine vesicular disease virus confers resistance to Golgi disrupting drugs

The amino acid substitution Q65H in the 2C protein of swine vesicular disease virus confers resistance to Golgi disrupting drugs

Swine vesicular disease virus (SVDV) is a porcine pathogen and a member of the species Enterovirus B within the Picornaviridae family. Brefeldin A (BFA) is an inhibitor of guanine nucleotide exchange factors of Arf proteins that induces Golgi complex disassembly and alters the cellular secretory pat...

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Bibliographic Details
Main Authors: Ángela eVázquez-Calvo, Flavia eCaridi, Mónica eGonzález-Magaldi, Juan-Carlos eSaiz, Francsico eSobrino Castello, Miguel A. Martín-Acebes
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Microbiology
Subjects:
Brefeldin A
Enterovirus
Golgi
Resistance
replication complex
mutant.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00612/full

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